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[25] [58] [2] [78] [65] Blood vessels in the nose are around five times more sensitive than the heart to the actions of circulating epinephrine (adrenaline), which may help to explain how pseudoephedrine at the low doses used in over-the-counter products can produce nasal decongestion with minimal effects on the heart. [2]
A wide variety of alkaloid and non-alkaloid compounds have been identified in various species of ephedra.Of the six ephedrine-type ingredients found in ephedra (at concentrations of 0.02-3.4%), the most common are ephedrine and pseudoephedrine, [12] which are the sources of its stimulant and thermogenic effects. [3]
The company's updated website attributes "changing [their] manufacturing location" for the supply disruption and currently states "it is unlikely product will be available in 2010". [2] However, the trade name Drixoral is now used in Canada for an oxymetazoline hydrochloride nasal spray.
Reported by the joint conference committee on December 8, 2005; agreed to by the House on December 14, 2005 (251-174, Roll call vote 627, via Clerk.House.gov, in lieu of H.R. 3199) and by the Senate on March 2, 2006 (89-10, Roll call vote 29, via Senate.gov, in lieu of H.R. 3199) Signed into law by President George W. Bush on March 9, 2006
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