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2,4-Dinitrophenol (2,4-DNP or simply DNP) is an organic compound with the formula HOC 6 H 3 (NO 2) 2. It has been used in explosives manufacturing and as a pesticide and herbicide. In humans, DNP causes dose-dependent mitochondrial uncoupling , causing the rapid loss of ATP as heat and leading to uncontrolled hyperthermia —up to 44 °C (111 ...
Dinitrophenols are chemical compounds which are nitro derivatives of phenol.. There are six isomers of dinitrophenol: Chemical structure of 2,4-Dinitrophenol. 2,3-Dinitrophenol; 2,4-Dinitrophenol
2,4-Dinitrophenol (DNP) is a very strong thermogenic drug used for fat loss which produces a dose-dependent increase in body temperature, to the point where it can induce death by hyperthermia. It works as a mitochondrial oxidative phosphorylation uncoupler, disrupting the mitochondrial electron transport chain .
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The human gene for CNP (NPPC), in contrast to the genes for ANP and BNP, is located on chromosome 2 and consists of just two exons and one intron. [3] The CNP gene is also located on chromosome 2 in mice. The 126 amino acids long protein produced by NPPC has a signal sequence of 23 amino acids and then a proCNP segment with 103 amino acids. [3]
“Fructose occurs naturally in some fruits and vegetables — so humans have always been exposed to it,” Gary Patti, PhD, the Michael and Tana Powell Professor of Chemistry, Genetics, and ...
DNP may refer to: Science and technology. 2,4-Dinitrophenol, a small organic molecule formerly marketed as a pharmaceutical "diet aid" Deoxyribonucleoprotein, a ...
Overdose caused fatal hyperthermia and DNP also caused cataracts in some users. After the passage of the Food, Drug, and Cosmetic Act in 1938, the FDA banned DNP for human consumption. [37] Amphetamines (marketed as Benzedrine) became popular for weight loss during the late 1930s. They worked primarily by suppressing appetite, and had other ...