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T h 1 cells can recruit other phagocytes to the site of the infection in several ways. They secrete cytokines that act on the bone marrow to stimulate the production of monocytes and neutrophils, and they secrete some of the cytokines that are responsible for the migration of monocytes and neutrophils out of the bloodstream. [78]
In immunology, the mononuclear phagocyte system or mononuclear phagocytic system (MPS) also known as the macrophage system is a part of the immune system that consists of the phagocytic cells [1] located in reticular connective tissue. The cells are primarily monocytes and macrophages, and they accumulate in lymph nodes and the spleen.
IL-3 and GM-CSF released by T H 1 cells stimulate more monocyte production in the bone marrow. [ 34 ] When intracellular pathogens cannot be eliminated, such as in the case of Mycobacterium tuberculosis , the pathogen is contained through the formation of granuloma , an aggregation of infected macrophages surrounded by activated T cells. [ 47 ]
Histiocytes are derived from the bone marrow by multiplication from a stem cell.The derived cells migrate from the bone marrow to the blood as monocytes.They circulate through the body and enter various organs, where they undergo differentiation into histiocytes, which are part of the mononuclear phagocytic system (MPS).
In anatomy the term reticuloendothelial system (abbreviated RES), often associated nowadays with the mononuclear phagocyte system (MPS), was employed by the beginning of the 20th century to denote a system of specialised cells that effectively clear colloidal vital stains (so called because they stain living cells) from the blood circulation ...
Megakaryocytes are derived from hematopoietic stem cell precursor cells in the bone marrow. They are produced primarily by the liver, kidney, spleen, and bone marrow. These multipotent stem cells live in the marrow sinusoids and are capable of producing all types of blood cells depending on the signals they receive.
An osteoclast is a large multinucleated cell and human osteoclasts on bone typically have four nuclei [5] and are 150–200 μm in diameter. When osteoclast-inducing cytokines are used to convert macrophages to osteoclasts, very large cells that may reach 100 μm in diameter occur. These may have dozens of nuclei, and typically express major ...
The megakaryoblast is derived from colony forming units (CFU-Meg) of hematopoietic stem cells found in red bone marrow. There are biomarkers found on the surface of hemopoietic stem cells that are used as identifiers for megakaryoblasts and other precursor cells. Two of the committed biomarkers are CD34-and CD150+. [6] The CFU-Meg, which forms ...