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  2. Immunoglobulin E - Wikipedia

    en.wikipedia.org/wiki/Immunoglobulin_E

    IgE primes the IgE-mediated allergic response by binding to Fc receptors found on the surface of mast cells and basophils. Fc receptors are also found on eosinophils, monocytes, macrophages and platelets in humans. There are two types of Fcε receptors: [citation needed] FcεRI (type I Fcε receptor), the high-affinity IgE receptor

  3. Isotype (immunology) - Wikipedia

    en.wikipedia.org/wiki/Isotype_(immunology)

    The IgG, IgE and IgA antibody isotypes are generated following class-switching during germinal centre reaction and provide different effector functions in response to specific antigens. IgG is the most abundant antibody class in the serum and it is divided into 4 subclasses based on differences in the structure of the constant region genes and ...

  4. Immunoglobulin class switching - Wikipedia

    en.wikipedia.org/wiki/Immunoglobulin_class_switching

    Mechanism of class-switch recombination that allows isotype switching in activated B cells. Immunoglobulin class switching, also known as isotype switching, isotypic commutation or class-switch recombination (CSR), is a biological mechanism that changes a B cell's production of immunoglobulin from one type to another, such as from the isotype IgM to the isotype IgG. [1]

  5. Doctors Say This Nighttime Behavior Can Be A Sign Of Dementia

    www.aol.com/doctors-nighttime-behavior-sign...

    Fred Kobylarz, MD, is co-director of the Center for Healthy Aging at Rutgers Robert Wood Johnson Medical School. ‘Sundowning’ is a term that refers to behavior changes in people with dementia ...

  6. Allergy - Wikipedia

    en.wikipedia.org/wiki/Allergy

    A major breakthrough in understanding the mechanisms of allergy was the discovery of the antibody class labeled immunoglobulin E (IgE). IgE was simultaneously discovered in 1966–67 by two independent groups: [ 167 ] Ishizaka 's team at the Children's Asthma Research Institute and Hospital in Denver, USA, [ 168 ] and by Gunnar Johansson and ...

  7. Dexter Morgan is alive in 'Original Sin,' as young serial ...

    www.aol.com/serial-killer-dexter-morgan-returns...

    With Christian Slater as dad Harry Morgan, Irish actor Patrick Gibson puts young life into TV's favorite serial killer in "Dexter: Original Sin."

  8. Unidentified male DNA found on JonBenét’s clothes - AOL

    www.aol.com/evidence-found-scene-jonben-t...

    The key to solving JonBenét Ramsey's murder could lie in evidence found at the scene nearly 30 years ago.. When police searched the 6-year-old’s home in Boulder, Colo., on Dec. 26, 1996, they ...

  9. Interleukin 4 - Wikipedia

    en.wikipedia.org/wiki/Interleukin_4

    Interleukin 4 mediates important pro-inflammatory functions in asthma, including induction of isotype rearrangement of IgE, expression of vascular cell adhesion molecule 1 (VCAM-1), promoting eosinophilic transmigration through endothelium, mucus secretion and T helper type 2 (T h 2) leading to cytokine release. Asthma is a complex genetic ...

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