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PeptiDream Announces License of PeptiDream's Peptide Discovery Platform System (PDPS) Technology to Bristol-Myers Squibb and Extension of the Macrocyclic Peptide Drug Discovery Alliance Between ...
Macrocyclic peptides are the “Goldilocks” chemical modality because their intermediate size combines the favorable properties of both small molecules and biologics. “I am thrilled to join UNP’s team of innovators in macrocyclic peptide drug discovery at such an exciting stage of the company,” said Bailey.
“RFpeptides is a novel deep learning pipeline that enables the precise design of macrocyclic peptide binders for a wide range of therapeutic protein targets,” said Gaurav Bhardwaj, Ph.D., Assistant Professor, Department of Medicinal Chemistry at UW School of Pharmacy and Institute for Protein Design at the University of Washington, and Co ...
Ipglycermides are non-natural macrocyclic peptide (MCP) inhibitors of cofactor independent phosphoglycerate mutases (iPGM) discovered by the research laboratories of Dr. James Inglese of the National Institutes of Health and Prof. Hiroaki Suga of the University of Tokyo.
Enlicitide chloride (INN; [1] previously known as MK-0616) is a macrocyclic peptide investigational drug who is being evaluated for the treatment of hypercholesterolaemia. It is a PCSK9 inhibitor. [2] Merck has launched a Phase 3 clinical trial to evaluate the efficacy and safety of MK-0616 in Adults With Hypercholesterolemia. [3] [4]
Thus, certain cystine knot proteins satisfy the basic criteria for drug delivery and represent exciting novel candidates as scaffolds for peptide drug delivery. [24] The diverse range of intrinsic activities of cyclotides also continues to hold promise for a wide range of applications in the agricultural fields against insects and nematodes ...
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Bottromycin is a macrocyclic peptide with antibiotic activity. It was first discovered in 1957 as a natural product isolated from Streptomyces bottropensis. [1] It has been shown to inhibit methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci among other Gram-positive bacteria and mycoplasma. [2]