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These polymers are derived from polystyrene by the addition of sulfonate functional groups. Sodium polystyrene sulfonate was approved for medical use in the United States in 1958. [1] A polystyrene sulfonate was developed in the 2000s to treat Clostridioides difficile associated diarrhea under the name Tolevamer, [2] but it was never marketed.
Potassium binders are medications that bind potassium ions in the gastrointestinal tract, thereby preventing its intestinal absorption. This category formerly consisted solely of polystyrene sulfonate, a polyanionic resin attached to a cation, administered either orally or by retention enema to patients who are at risk of developing hyperkalaemia (abnormal high serum potassium levels).
ATC code V03 All other therapeutic products is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
Polystyrene sulfonate, a cation-exchange resin, is typically supplied with Na + as the counterion. In chemistry , a counterion (sometimes written as " counter ion ", pronounced as such) is the ion that accompanies an ionic species in order to maintain electric neutrality.
Tolevamer was designed to bind the enterotoxins of Clostridioides difficile.Since it has no antibiotic properties, it does not harm the gut flora.Early studies used the sodium salt, but it was soon replaced with the potassium sodium salt to prevent hypokalaemia, which is often associated with diarrhea.
Poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) is a composite material where PEDOT (the conductive polymer) provides electrical conductivity, and PSS (polystyrene sulfonate) acts as a counter-ion to balance the charge and improve the water solubility and processability of PEDOT.
Sodium zirconium cyclosilicate, sold under the brand name Lokelma, is a medication used to treat high blood potassium. [5] Onset of effects occurs in one to six hours. [5] It is taken by mouth. [5] Common side effects include swelling and low blood potassium. [5] Use is likely safe in pregnancy and breastfeeding. [5]
Phosphate binders may be simple molecular entities (such as magnesium, aluminium, calcium, or lanthanum salts) that react with phosphate and form an insoluble compound. Calcium carbonate Calcium-based phosphate binders, such as calcium carbonate, directly decrease phosphate levels by creating insoluble calcium–phosphate complexes which gets ...