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However, environmental factors (almost certainly diet and weight) play a large part in the development of type 2 diabetes in addition to any genetic component. Genetic risk for type 2 diabetes changes as humans first began migrating around the world, implying a strong environmental component has affected the genetic-basis of type 2 diabetes.
Dietary factors also influence the risk of developing type 2 diabetes. Consumption of sugar-sweetened drinks in excess is associated with an increased risk. [ 39 ] [ 40 ] The type of fats in the diet are important, with saturated fat and trans fatty acids increasing the risk, and polyunsaturated and monounsaturated fat decreasing the risk. [ 32 ]
Obesity has been found to contribute to approximately 55% of cases of type 2 diabetes; [10] chronic obesity leads to increased insulin resistance that can develop into type 2 diabetes, [11] most likely because adipose tissue (especially that in the abdomen around internal organs) is a source of several chemical signals, hormones and cytokines, to other tissues.
A fasting blood sugar level of ≥ 7.0 mmol / L (126 mg/dL) is used in the general diagnosis of diabetes. [17] There are no clear guidelines for the diagnosis of LADA, but the criteria often used are that the patient should develop the disease in adulthood, not need insulin treatment for the first 6 months after diagnosis and have autoantibodies in the blood.
In people with impaired glucose tolerance or impaired fasting glucose, presence of metabolic syndrome doubles the risk of developing type 2 diabetes. [37] It is likely that prediabetes and metabolic syndrome denote the same disorder, defining it by the different sets of biological markers.
Getting diagnosed with type 2 diabetes before the age of 50 may increase one's risk of developing dementia by 1.9 times, a new study has found. ... are developing type 2 diabetes before the age of ...
[3] [4] [5] Some non-modifiable risk factors such as age at diabetes onset, type of diabetes, gender, and genetics may influence risk. Other health problems compound the chronic complications of diabetes such as smoking , obesity , high blood pressure , elevated cholesterol levels, and lack of regular exercise .
In 2021 there were 4.1 million people in the UK diagnosed with diabetes, 90% of them having type 2. There were a further 1 million people with undiagnosed type 2 diabetes and 13.6 million people were at risk of developing type 2 diabetes, half of which could be prevented. [24]
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