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[18] 30.4–88.9% of those with antisynthetase syndrome report persistent muscular tenderness and myalgia. [19] [20] In antisynthetase syndrome, arthritis is commonly described as a symmetrical, non-erosive polyarthritis of the small hands and feet that can sometimes mimic CTD-associated, rheumatoid, and seronegative inflammatory arthritis. [21]
In children, the pathophysiology involves a genetic component, exposure-related injury, autoimmune dysregulation, or all of the components. [ 7 ] Thirty to 40% of those with interstitial lung disease eventually develop pulmonary fibrosis which has a median survival of 2.5-3.5 years. [ 8 ]
Over time, affected children experience mental impairment, worsening seizures and progressive loss of sight, speech and motor skills. Batten disease is a terminal disease; life expectancy varies depending on the type or variation. [7] [8] Females with juvenile Batten disease show first symptoms a year later than males, but on average die a year ...
PM/Scl overlap syndrome Scleromyositis , is an autoimmune disease (a disease in which the immune system attacks the body). People with scleromyositis have symptoms of both systemic scleroderma and either polymyositis or dermatomyositis , and is therefore considered an overlap syndrome .
From November 1995 to November 1996 in France, a national survey of pediatric departments for children under 15 years of age with unexplained encephalopathy and a threefold (or greater) increase in serum aminotransferase and/or ammonia led to the identification of nine definite cases of Reye syndrome (0.79 cases per million children). Eight of ...
During the next 15 years the underlying defect remained unknown but since the plasmaprotein transferrin was underglycosylated (as shown by e.g. isoelectric focusing), the new syndrome was named carbohydrate-deficient glycoprotein syndrome (CDGS) [1] Its "classic" phenotype included psychomotor retardation, ataxia, strabismus, anomalies (fat ...
Clueless lefty protesters interrupt USAID hearing, get savaged for being wrong about AIDS funding
The most severely impaired children do not walk or acquire language, but the typical patient learns to walk and speak and has normal life expectancy. The MRI shows arrested or delayed myelination. [6] Approximately two-thirds of children with mild FSASD eventually learn to walk. Some degree of speech impairment is usually present.
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