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The control of ventilation is the physiological mechanisms involved in the control of breathing, which is the movement of air into and out of the lungs. Ventilation facilitates respiration. Respiration refers to the utilization of oxygen and balancing of carbon dioxide by the body as a whole, or by individual cells in cellular respiration. [1]
The partial pressure of carbon dioxide, along with the pH, can be used to differentiate between metabolic acidosis, metabolic alkalosis, respiratory acidosis, and respiratory alkalosis. Hypoventilation exists when the ratio of carbon dioxide production to alveolar ventilation increases above normal values – greater than 45mmHg.
This slight negative pressure is enough to move 500 ml of air into the lungs in the 2 seconds required for inspiration. At the end of inspiration, the alveolar pressure returns to atmospheric pressure (zero cmH 2 O). [2] During exhalation, the opposite change occurs. The lung alveoli collapse before air is expelled from them.
Real-time magnetic resonance imaging of the human thorax during breathing X-ray video of a female American alligator while breathing. Breathing (spiration [1] or ventilation) is the rhythmical process of moving air into and out of the lungs to facilitate gas exchange with the internal environment, mostly to flush out carbon dioxide and bring in oxygen.
The differences between the atmospheric and intrapulmonary pressures, driving air in and out of the lungs during the breathing cycle, are in the region of only 2–3 kPa. [18] [19] A doubling or more of these small pressure differences could be achieved only by very major changes in the breathing effort at high altitudes.
Transpulmonary pressure is the difference between the alveolar pressure and the intrapleural pressure in the pleural cavity. During human ventilation, air flows because of pressure gradients. P tp = P alv – P ip. Where P tp is transpulmonary pressure, P alv is alveolar pressure, and P ip is intrapleural pressure.
The alveolar air pressure is therefore always close to atmospheric air pressure (about 100 kPa at sea level) at rest, with the pressure gradients that cause air to move in and out of the lungs during breathing rarely exceeding 2–3 kPa. [8] [9] Other muscles that can be involved in inhalation include: [10] External intercostal muscles; Scalene ...
The process of breathing does not fill the alveoli with atmospheric air during each inhalation (about 350 ml per breath), but the inhaled air is carefully diluted and thoroughly mixed with a large volume of gas (about 2.5 liters in adult humans) known as the functional residual capacity which remains in the lungs after each exhalation, and ...