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The rapid plasma reagin test (RPR test or RPR titer) is a type of rapid diagnostic test that looks for non-specific antibodies in the blood of the patient that may indicate an infection by syphilis or related non-venereal treponematoses. It is one of several nontreponemal tests for syphilis (along with the Wassermann test and the VDRL test).
With nontreponemal tests, false-positive reactions can occur for a large number of reasons, the most common of which is other infections, both viral and bacterial. Additionally these tests may show false-negative when the patient's antibody titer is very high due to a hook effect (also called a prozone effect).
Serological assays may give a false positive result, causing the individual to appear to have seroconverted when the individual has not. False positives can occur due to the test reacting to, or detecting, an antibody that happens to be sufficiently similar in structure to the target antibody.
The Wassermann test or Wassermann reaction (WR) [1] is an antibody test for syphilis, named after the bacteriologist August Paul von Wassermann, based on complement fixation. It was the first blood test for syphilis and the first in the nontreponemal test (NTT) category. Newer NTTs, such as the RPR and VDRL tests, have mostly
The rapid plasma reagin (RPR) test uses the same antigen as the VDRL, but in that test, it has been bound to several other molecules, including a carbon particle to allow visualization of the flocculation reaction without the need of a microscope. Many other medical conditions can produce false positive results, including some viruses ...
A false positive Covid-19 test result can happen, but it’s rare, says Brian Labus, Ph.D., M.P.H., assistant professor at the University of Nevada Las Vegas School of Public Health.
Fig. 1: Microwells showing positive and negative TPHA test. The Treponema pallidum particle agglutination assay (also called TPPA test) is an indirect agglutination assay used for detection and titration of antibodies against the causative agent of syphilis, Treponema pallidum subspecies pallidum. It also detects other treponematoses. [citation ...
False positive COVID-19 tests—when your result is positive, but you aren’t actually infected with the SARS-CoV-2 virus—are a real, if unlikely, possibility, especially if you don’t perform ...