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  2. EC50 - Wikipedia

    en.wikipedia.org/wiki/EC50

    For clarification, a graded dose response curve shows the graded effect of the drug (y axis) over the dose of the drug (x axis) in one or an average of subjects. A quantal dose response curve shows the percentage of subjects where a response is noted in an all-or-none manner (y axis) over the dose of the drug (x axis).

  3. Effective dose (pharmacology) - Wikipedia

    en.wikipedia.org/wiki/Effective_dose_(pharmacology)

    The ED50 is commonly used as a measure of the reasonable expectancy of a drug effect, but does not necessarily represent the dose that a clinician might use. This depends on the need for the effect, and also the toxicity. The toxicity and even the lethality of a drug can be quantified by the TD 50 and LD 50 respectively. Ideally, the effective ...

  4. Therapeutic index - Wikipedia

    en.wikipedia.org/wiki/Therapeutic_index

    A higher safety-based therapeutic index is preferable instead of a lower one; an individual would have to take a much higher dose of a drug to reach the lethal threshold than the dose taken to induce the therapeutic effect of the drug. However, a lower efficacy-based therapeutic index is preferable instead of a higher one; an individual would ...

  5. What You Need to Know About Medicare Prescription Drug Plans ...

    www.aol.com/know-medicare-prescription-drug...

    Medigap plans: Medigap (Medicare supplemental insurance) plans help pay for out-of-pocket costs. If you bought your plan before January 1, 2006, you might have prescription medication coverage, too.

  6. Dose–response relationship - Wikipedia

    en.wikipedia.org/wiki/Dose–response_relationship

    The U.S. Food and Drug Administration also has guidance to elucidate dose–response relationships [3] during drug development. Dose response relationships may be used in individuals or in populations. The adage The dose makes the poison reflects how a small amount of a toxin has no significant effect, while a large amount may be fatal. This ...

  7. Equianalgesic - Wikipedia

    en.wikipedia.org/wiki/Equianalgesic

    Some patients request to be switched to a different narcotic due to stigma associated with a particular drug (e.g. a patient refusing methadone due to its association with opioid addiction treatment). [4] Equianalgesic charts are also used when calculating an equivalent dosage of the same drug, but with a different route of administration.

  8. Intrinsic activity - Wikipedia

    en.wikipedia.org/wiki/Intrinsic_activity

    Intrinsic activity (IA) and efficacy (E max) refer to the relative ability of a drug-receptor complex to produce a maximum functional response. This must be distinguished from the affinity, which is a measure of the ability of the drug to bind to its molecular target, and the EC 50, which is a measure of the potency of the drug and which is proportional to both efficacy and affinity.

  9. Medicare Price Cuts for 10 Common Prescription Drugs ... - AOL

    www.aol.com/lifestyle/medicare-price-cuts-10...

    Previously, individual Medicare plans were able to negotiate prescription drug prices, but Medicare was banned from using its leverage to negotiate prices for the program as a whole.

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