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Anti-double stranded DNA (Anti-dsDNA) antibodies are a group of anti-nuclear antibodies (ANA) the target antigen of which is double stranded DNA. Blood tests such as enzyme-linked immunosorbent assay (ELISA) and immunofluorescence are routinely performed to detect anti-dsDNA antibodies in diagnostic laboratories.
The presence of anti-dsDNA antibodies is also linked with lupus nephritis and there is evidence they are the cause. Some anti-dsDNA antibodies are cross reactive with other antigens found on the glomerular basement membrane (GBM) of the kidney, such as heparan sulphate, collagen IV, fibronectin and laminin.
The anti-dsDNA antibody titers also tend to reflect disease activity, although not in all cases. [13] Other ANA that may occur in people with SLE are anti-U1 RNP (which also appears in systemic sclerosis and mixed connective tissue disease), SS-A (or anti-Ro) and SS-B (or anti-La; both of which are more common in Sjögren's syndrome). SS-A and ...
Anti-actin antibodies; Anti-dsDNA antibodies; Anti-glomerular basement membrane antibody; Anti-glutamate receptor antibodies; Anti-histone antibodies; Anti-Jo1; Anti-neutrophil cytoplasmic antibody; Anti-nRNP; Anti-Scl-70 antibodies; Anti-smooth muscle antibody; Anti-sp100 antibodies; Anti-SSA/Ro autoantibodies; Antisperm antibodies ...
Anti-CEA antibody; Anti-cholesterol; Anti-DNase B; Anti-immunoglobulin; Anti-LKM antibody; Anti-streptolysin O; Antibody testing; Antinuclear antibody; Antisperm antibodies; Antithyroid autoantibodies; Autoantibody
In SLE, anti-DNA antibodies and anti-cardiolipin antibodies may be present individually or together; the two types of antibodies act independently. [5] This is in contrast to rheumatoid arthritis [ 6 ] with systemic sclerosis ( scleroderma ) [ 7 ] because anti-cardiolipin antibodies are present in both conditions, and therefore may tie the two ...
the presence of anti-dsDNA, anti-Sm and anti-cardiolipin autoantibodies correlates with the development of systemic lupus erythematosus in particular. [ 19 ] The rate of progression is higher in the first five years following the onset of the disease and tends to decrease over time.
The kinetoplast found in C. luciliae allows them to be used for the detection of anti-dsDNA antibodies, a type of anti-nuclear antibody. Anti-nuclear antibodies are a common feature in SLE, and anti-dsDNA antibodies are highly specific for the disease. The high concentration of dsDNA and the absence of human nuclear antigens in the kinetoplast ...