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Polysorbate 80 is a surfactant and solubilizer used in a variety of oral and topical pharmaceutical products. Polysorbate 80 is also an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the making of the antiarrhythmic amiodarone . [ 9 ]
Polysorbate 60 (polyoxyethylene (20) sorbitan monostearate) Polysorbate 80 (polyoxyethylene (20) sorbitan monooleate) The number following the 'polysorbate' part is related to the type of major fatty acid associated with the molecule. Monolaurate is indicated by 20, monopalmitate is indicated by 40, monostearate by 60, and monooleate by 80.
Thus, intrinsic estrogenic effects of polysorbate 80 reported following its intraperitoneal injection to neonatal 4-day-old female rats are not manifest when it is administered by oral gavage to immature 20- to 22-day-old female rats. This latter route of exposure is of more relevance to human exposure scenarios and these data are, therefore ...
Docetaxel is a white powder and is the active ingredient available in 20 mg and 80 mg Taxotere single-dose vials of concentrated anhydrous docetaxel in polysorbate 80. [16] [17] The solution is a clear brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL.
7. Soy Can Affect Fertility in Men. Soy has come a long way. Once dismissed as “hippie food,” today it’s a popular protein alternative for vegetarians and vegans.
Antifoaming agents reduce or prevent foaming in foods. Antioxidants Antioxidants such as vitamin C act as preservatives by inhibiting the effects of oxygen on food, and can be beneficial to health. Bulking agents Bulking agents such as starch are additives that increase the bulk of a food without affecting its nutritional value. Food coloring
Radical Eats. Snack foods, insta-meals, cereals, and drinks tend to come and go, but the ones we remember from childhood seem to stick with us. Children of the 1970s and 1980s had a veritable ...
Coating these polymeric nanoparticle devices with different surfactants can also aid BBB crossing and uptake in the brain. Surfactants such as polysorbate 80, 20, 40, 60, and poloxamer 188, demonstrated positive drug delivery through the blood–brain barrier, whereas other surfactants did not yield the same results. [2]