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Triamcinolone is a synthetic pregnane corticosteroid and derivative of cortisol (hydrocortisone) and is also known as 1-dehydro-9α-fluoro-16α-hydroxyhydrocortisone or 9α-fluoro-16α-hydroxyprednisolone as well as 9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione.
It is a more potent derivative of triamcinolone, and is about eight times as potent as prednisone. [14] Most forms of triamcinolone acetonide are prescription drugs. In 2014, the U.S. Food and Drug Administration (FDA) made triamcinolone acetonide an over-the-counter drug in the United States in nasal spray form under the brand name Nasacort. [14]
Triamcinolone may interact with medications which are CYP3A4 inhibitors. CYP3A4 inhibitor may decrease the break down of triamcinolone which increases its amount in patients' body to cause toxicity. [6] Examples of CYP3A4 inhibitors include clarithromycin, verapamil, ketoconazole and anti-viral drugs, including nirmatrelvir and ritonavir. [7]
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Triamcinolone hexacetonide (brand name Aristospan; also known as triamcinolone acetonide 21-tebutate) is a synthetic glucocorticoid corticosteroid. [ 3 ] [ 4 ] [ 5 ] It is on the World Health Organization's List of Essential Medicines .
Triamcinolone benetonide (brand names Alcorten, Benecorten, Tibicorten; also known as triamcinolone acetonide 21-(benzoyl-β-aminoisobutyrate) or TBI) is a synthetic glucocorticoid corticosteroid. [ 1 ] [ 2 ] [ 3 ]
Triamcinolone acetonide phosphate; Triamcinolone acetonide succinate (triamcinolone acetonide hemisuccinate) Triamcinolone benetonide (triamcinolone acetonide 21-(benzoyl-β-aminoisobutyrate)) Triamcinolone furetonide (triamcinolone acetonide 21-(2-benzofurancarboxylate)) Triamcinolone hexacetonide (triamcinolone acetonide 21-(tert-butylacetate))
Triamcinolone furetonide (developmental code name HE-192; also known as triamcinolone acetonide 21-(2-benzofurancarboxylate)) is a synthetic glucocorticoid corticosteroid which was never marketed. [ 1 ] [ 2 ] [ 3 ]