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Certolizumab pegol, sold under the brand name Cimzia, is a biopharmaceutical medication for the treatment of Crohn's disease, [4] [5] rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. It is a fragment of a monoclonal antibody specific to tumor necrosis factor alpha (TNF-α) and is manufactured by UCB. [6] [7] [2]
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Most biologics are injections so are not appropriate for use by someone with intense fear of needles. [4] A person with any infection should not use biologics. [4] Other contraindications for biologics include cancer, certain neurologic disorders, being pregnant or breastfeeding, history of heart failure, or history of tuberculosis. [4]
IM Tooltip Intramuscular or SC injection: Estradiol valerate – – 4 mg 1x/4 weeks Estradiol cypionate: 1 mg 1x/3–4 weeks: 3 mg 1x/3–4 weeks: 5 mg 1x/3–4 weeks Estradiol benzoate: 0.5 mg 1x/week: 1 mg 1x/week: 1.5 mg 1x/week SC implant: Estradiol: 25 mg 1x/6 months: 50 mg 1x/6 months: 100 mg 1x/6 months
Clinical trial number NCT05232825 for "A Phase III, Non-Inferiority, Randomized, Open-Label, Parallel Group, Multicenter Study To Investigate The Pharmacokinetics, Pharmacodynamics, Safety And Radiological And Clinical Effects Of Subcutaneous Ocrelizumab Versus Intravenous Ocrelizumab In Patients With Multiple Sclerosis (Ocarina II)" at ClinicalTrials.gov
Cimzia: Fab' humanized: TNF-α: Y: Crohn's disease, rheumatoid arthritis, axial spondyloarthritis, psoriasis arthritis: Cetrelimab [5] mab: human: PD-1: cancer Cetuximab [32] Erbitux: mab: chimeric: Epidermal growth factor receptor (EGFR) Y: metastatic colorectal cancer and head and neck cancer: Cibisatamab [5] mab: humanized: CEACAM5: cancer ...
Depot injections can be created by modifying the drug molecule itself, as in the case of prodrugs, or by modifying the way it is administered, as in the case of oil/lipid suspensions. Depot injections can have a duration of action of one month or greater and are available for many types of drugs, including antipsychotics and hormones.
When used as a form of injected birth control, there is a delayed return of fertility. The average return to fertility is 9 to 10 months after the last injection, taking longer for overweight or obese women. By 18 months after the last injection, fertility is the same as that in former users of other contraceptive methods.