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Bactrim, Bactrimel (manufactured by Roche and distributed in Europe) Bactrom (Venezuela) Bibactin (manufactured by PPM and distributed in Cambodia and some African countries) Biseptol; Sumetrolim; Co-trimoxazole (used as generic UK name) Cotrim; Deprim (AFT Pharmaceuticals) Diseptyl (Israel)
Absorption. Sulfamethoxazole is well-absorbed when administered topically. It is rapidly absorbed when it is orally administered. [1] Distribution. Sulfamethoxazole distributes into most body tissues as well as into sputum, vaginal fluid, and middle ear fluid. [8] [11] It also crosses the placenta. About 70% of the drug is bound to plasma proteins.
In other cases, topical is defined as applied to a localized area of the body or to the surface of a body part regardless of the location of the effect. [4] [5] By this definition, topical administration also includes transdermal application, where the substance is administered onto the skin but is absorbed into the body to attain systemic ...
Trimethoprim (TMP) is an antibiotic used mainly in the treatment of bladder infections. [1] Other uses include for middle ear infections and travelers' diarrhea. [1] With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS.
Drug delivery to the brain is the process of passing therapeutically active molecules across the blood–brain barrier into the brain.This is a complex process that must take into account the complex anatomy of the brain as well as the restrictions imposed by the special junctions of the blood–brain barrier.
Distribution in pharmacology is a branch of pharmacokinetics which describes the reversible transfer of a drug from one location to another within the body.. Once a drug enters into systemic circulation by absorption or direct administration, it must be distributed into interstitial and intracellular fluids.
Therefore, bioavailability for dietary supplements can be defined as the proportion of the administered substance capable of being absorbed and available for use or storage. [11] In both pharmacology and nutrition sciences, bioavailability is measured by calculating the area under curve (AUC) of the drug concentration time profile.
Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems. More generally, xenobiotic metabolism (from the Greek xenos "stranger" and biotic "related to living beings") is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organism's normal biochemistry, such as any drug ...
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