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Benfotiamine (rINN, or S-benzoylthiamine O-monophosphate) is a synthetic, fat-soluble, S-acyl derivative of thiamine (vitamin B1) that is approved in some countries as a medication or dietary supplement to treat diabetic sensorimotor polyneuropathy. Benfotiamine was developed in late 1950s in Japan.
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A 2007 review of studies found ... Benfotiamine is an oral prodrug of Vitamin B1 that has several placebo-controlled double-blind trials proving efficacy in ...
Alpha lipoic acid (ALA) with benfotiamine is a proposed pathogenic treatment for painful diabetic neuropathy only. [119] The results of two systematic reviews state that oral ALA produced no clinically significant benefit, intravenous ALA administered over three weeks may improve symptoms and that long-term treatment has not been investigated ...
B1 is typically only water soluble. Note that a substance can also be fat and water soluble, although there is no indication that benfotiamine is such a substance. --IO Device 18:42, 6 November 2011 (UTC) benfotiamine is a fat soluble form of thiamine. B1 is tradiitonally considered water soluble because most B1 is in the thiamine form.
Thiamine is one of the B vitamins and is also known as vitamin B 1. [1] [11] [12] It is a cation that is usually supplied as a chloride salt. [3]It is soluble in water, methanol and glycerol, but practically insoluble in less polar organic solvents.
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List of B vitamins Vitamin Name Description Vitamin B 1: Thiamine: A coenzyme in the catabolism of sugars and amino acids.: Vitamin B 2: Riboflavin: A precursor of coenzymes called FAD and FMN, which are needed for flavoprotein enzyme reactions, including activation of other vitamins
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