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Aducanumab, sold under the brand name Aduhelm, is a monoclonal antibody designed to treat Alzheimer's disease. It is a monoclonal antibody that targets aggregated forms (plaque) of amyloid beta (Aβ) found in the brains of people with Alzheimer's disease to reduce its buildup. [10] It was developed by Biogen and Eisai. [11] Aducanumab is given via intravenous infusion. [5] Aducanumab was ...
Aducanumab, an antibody-targeting amyloid-beta protein deposits, received Food and Drug Administration (FDA) approval for the treatment of Alzheimer’s disease in 2021, and was considered the ...
The Food and Drug Administration (FDA) approved lecanemab, sold under the brand name Leqembi — the first anti-amyloid medication for the treatment of Alzheimer’s disease.
The drug works by reducing amyloid plaques that form in the brain, which is a hallmark of Alzheimer’s disease. With this, it helps slow the progression of the disease. Lecanemab is given to ...
Eplontersen, sold under the brand name Wainua, is a medication used for the treatment of transthyretin-mediated amyloidosis. [3] It is a transthyretin-directed antisense oligonucleotide. [3]
The US Food and Drug Administration (FDA) label for donanemab contains a boxed warning about amyloid-related imaging abnormalities. [1]Side effects may include infusion-related reactions, with symptoms such as flu-like symptoms, nausea, vomiting and changes in blood pressure, and hypersensitivity reactions, including anaphylaxis (severe, life-threatening allergic reaction) and angioedema ...
A US Food and Drug Administration spokesperson said the agency was aware of the potential exclusion of some African Americans from the new treatments due to insufficient amyloid levels ...
To date, 37 human proteins have been found to form amyloid in pathology and be associated with well-defined diseases. [2] The International Society of Amyloidosis classifies amyloid fibrils and their associated diseases based upon associated proteins (for example ATTR is the group of diseases and associated fibrils formed by TTR). [3]