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In broad usage, the "practical clinical significance" answers the question, how effective is the intervention or treatment, or how much change does the treatment cause. In terms of testing clinical treatments, practical significance optimally yields quantified information about the importance of a finding, using metrics such as effect size, number needed to treat (NNT), and preventive fraction ...
A clinical researcher might report: "in my own experience treatment X does not do well for condition Y". [3] [4] The use of a P value cut-off point of 0.05 was introduced by R.A. Fisher; this led to study results being described as either statistically significant or non-significant. [5]
clinically significant macular edema: CSOM: chronic suppurative otitis media: CSPC: community specialist palliative care: C-spine: cervical spine: CSR: cumulative survival rate: C-SSRS: Columbia Suicide Severity Rating Scale: CSU: catheter specimen of urine CST: contraction stress test: CT: computed tomography cervicothoracic: CTA: clear to ...
An indication can commonly be confused with the term diagnosis. A diagnosis is the assessment that a particular medical condition is present while an indication is a reason for use. [3] The opposite of an indication is a contraindication, [4] a reason to withhold a certain medical treatment because the risks of treatment clearly outweigh the ...
If a clinical endpoint is devastating enough (e.g. death, heart attack), drugs with a high NNT may still be indicated in particular situations. If the endpoint is minor, health insurers may decline to reimburse drugs with a high NNT. NNT is significant to consider when comparing possible side effects of a medication against its benefits.
Clinical research is a branch of medical research that involves people and aims to determine the effectiveness and safety of medications, devices, diagnostic products, and treatment regimens intended for improving human health.
Clinical endpoints or clinical outcomes are outcome measures referring to occurrence of disease, symptom, sign or laboratory abnormality constituting a target outcome in clinical research trials. The term may also refer to any disease or sign that strongly motivates withdrawal of an individual or entity from the trial, then often termed a ...
Clinical peer review, also known as medical peer review is the process by which health care professionals, including those in nursing and pharmacy, evaluate each other's clinical performance. [ 1 ] [ 2 ] A discipline-specific process may be referenced accordingly (e.g., physician peer review , nursing peer review ).