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Antihypertensive agents comprise multiple classes of compounds that are intended to manage hypertension (high blood pressure). Antihypertensive therapy aims to maintain a blood pressure goal of <140/90 mmHg in all patients, as well as to prevent the progression or recurrence of cardiovascular diseases (CVD) in hypertensive patients with established CVD. [2]
Guidelines by the American College of Cardiology and the American Heart Association recommend statin treatment for primary prevention of cardiovascular disease in adults with LDL cholesterol ≥ 190 mg/dL (4.9 mmol/L) or those with diabetes, age 40–75 with LDL-C 70–190 mg/dL (1.8–4.9 mmol/dL); or in those with a 10-year risk of developing ...
In 2018, the American Heart Association and American College of Cardiology issued new guidelines for clinicians on the management of cholesterol as a way to reduce risk for heart attack and stroke. Newly included in the guidelines is a recommendation to use coronary artery calcium score if healthcare providers are having difficulty deciding if ...
The diet was incorporated into the Adult Treatment Panel III (ATP III) for high cholesterol in adults which was released in 2002. Updated guidelines for cholesterol management were established in 2013 by the American Heart Association (AHA) and American College of Cardiology (ACC). [4]
Rates of high total cholesterol in the United States in 2010 are just over 13%, down from 17% in 2000. [89] Average total cholesterol in the United Kingdom is 5.9 mmol/L, while in rural China and Japan, average total cholesterol is 4 mmol/L. [10] Rates of coronary artery disease are high in Great Britain, but low in rural China and Japan. [10]
The cholesterol lowering effect of fibrates is due to their ability to activate a nuclear receptor called peroxisome proliferator activated receptor alpha. [ 20 ] [ 21 ] They include fenofibrate, gemfibrozil, and bezafibrate and work to decrease triglycerides, increase HDL-C, and also decrease LDL-C which is variable depending on which drug is ...
Michos has participated in multiple national and international society guidelines and position statements including the 2019 American College of Cardiology (ACC)/American Heart Association (AHA) guideline to update recommendations for the primary prevention of cardiovascular disease. [10]
Hyperlipidemia is abnormally high levels of any or all lipids (e.g. fats, triglycerides, cholesterol, phospholipids) or lipoproteins in the blood. [2] The term hyperlipidemia refers to the laboratory finding itself and is also used as an umbrella term covering any of various acquired or genetic disorders that result in that finding. [3]