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Hemosiderin or haemosiderin is an iron-storage complex that is composed of partially digested ferritin and lysosomes. The breakdown of heme gives rise to biliverdin and iron. [1] [2] The body then traps the released iron and stores it as hemosiderin in tissues. [3] Hemosiderin is also generated from the abnormal metabolic pathway of ferritin. [3]
Hemosiderin hyperpigmentation is pigmentation due to deposits of hemosiderin, and occurs in purpura, haemochromatosis, hemorrhagic diseases, and stasis dermatitis. [ 1 ] : 853 See also
Hemosiderin deposition in the lungs is often seen after diffuse alveolar hemorrhage, which occurs in diseases such as Goodpasture's syndrome, granulomatosis with polyangiitis, and idiopathic pulmonary hemosiderosis. Mitral stenosis can also lead to pulmonary hemosiderosis. Hemosiderin collects throughout the body in hemochromatosis.
The stain is an important histochemical stain used to demonstrate the distribution and amount of iron deposits in liver tissue, often in the form of a biopsy. [ 6 ] [ 7 ] Perls's procedure may be used to identify excess iron deposits such as hemosiderin deposits ( hemosiderosis ) and in conditions such as hereditary hemochromatosis . [ 8 ]
Hemosiderinuria (syn. haemosiderinuria) is the presence of hemosiderin in urine. [1] It is often the result of chronic intravascular hemolysis, in which hemoglobin is released from red blood cells into the bloodstream in excess of the binding capacity of haptoglobin. The function of haptoglobin is to bind to circulating hemoglobin, thereby ...
Iron overload (also known as haemochromatosis or hemochromatosis) is the abnormal and increased accumulation of total iron in the body, leading to organ damage. [1] The primary mechanism of organ damage is oxidative stress, as elevated intracellular iron levels increase free radical formation via the Fenton reaction.
T 2 *-weighted sequences are used to detect deoxygenated hemoglobin, methemoglobin, or hemosiderin in lesions and tissues. [2] Diseases with such patterns include intracranial hemorrhage, arteriovenous malformation, cavernoma, hemorrhage in a tumor, punctate hemorrhages in diffuse axonal injury, superficial siderosis, thrombosed aneurysm, phleboliths in vascular lesions, and some forms of ...
[5] [8] [14] Later stages show significant hemosiderin deposition in the stroma, fibrosis, and a collapsed appearance of the arterial lumen. [8] [14] Clinical differential diagnoses include infantile hemangioma, melanocytic lesions, tufted angioma, insect bite, Kaposi sarcoma, erythema multiforme, and dermatofibroma, depending on the stage of ...