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Dr. Thomas Aoki, former Head of Metabolism Research at the Joslin Diabetes Center in Boston, Massachusetts, and a former Professor of Medicine at the University of California, Davis, led the field as a pioneer of using pulsatile insulin in the treatment of diabetes. Aoki's work focused on the role of liver dysfunction in diabetic metabolism.
PK/PD relationships can be described by simple equations such as linear model, Emax model or sigmoid Emax model. [5] However, if a delay is observed between the drug administration and the drug effect, a temporal dissociation needs to be taken into account and more complex models exist: [6] [7] Direct vs Indirect link PK/PD models
Drug delivery systems have been around for many years, but there are a few recent applications of drug delivery that warrant 1. Drug delivery to the brain: Many drugs can be harmful when administered systemically; the brain is very sensitive to medications and can easily cause damage if a drug is administered directly into the bloodstream.
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Stanford Cardiovascular Institute - the nucleus for cardiovascular research at Stanford University and home to myriad cardiovascular-related adult and pediatric research, clinical, and educational programs, centers and laboratories, as well as over 500 Stanford basic scientists, graduate students, clinician scientists, and other researchers in ...
The following persons have been or are editor-in-chief of the Journal of Nursing Education: Alice Bicknell (1962) Editorial board (1963–1980) Margaret Carnine (1981–1982) Rheba de Tornyay (1983–1990) Christine A. Tanner (1991–2012) Janis P. Bellack (2012–2018) Amy J. Barton (2018–present)
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A third class of system (pulse dose oxygen conserving device, or demand pulse devices) senses the start of inhalation and provides a metered bolus, which if correctly matched to requirements, will be sufficient and effectively inhaled into the alveoli.Such systems can be pneumatically or electrically controlled.