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Intractable pain, also called intractable pain syndrome (IPS), is a severe, constant, relentless, and debilitating pain that is not curable by any known means and which causes a house-bound or bed-bound state and early death if not adequately treated, usually with opioids and/or interventional procedures. It is not relieved by ordinary medical ...
The effect of treatment of blood pressure between 130/80 mmHg and 160/100 mmHg is less clear, with some reviews finding benefit [6] [16] [17] [18] and others finding unclear benefit. [19] [20] High blood pressure affects 33% of the population globally. [9] About half of all people with high blood pressure do not know that they have it. [9]
The paroxysm is said to be similar to the hypertensive episodes described by Page in 1935, and has been colloquially referred to as "Page's Syndrome". These episodes can occur after diencephalic stimulation. [1] The exact cause of pseudopheochromocytoma is unknown, though it is thought to be related to episodic dopamine discharge.
"Your blood pressure is supposed to be under 140 over 90, optimally closer to 120 over 80."
Explanatory model of chronic pain. Chronic pain is defined as reoccurring or persistent pain lasting more than 3 months. [1] The International Association for the Study of Pain (IASP) defines pain as "An unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage". [2]
For most people, recommendations are to reduce blood pressure to less than or equal to somewhere between 140/90 mmHg and 160/100 mmHg. [2] In general, for people with elevated blood pressure, attempting to achieve lower levels of blood pressure than the recommended 140/90 mmHg will create more harm than benefits, [3] in particular for older people. [4]
Goal blood pressure (mmHg) Initial treatment options ESC 2024 [2] General 120–129/70–79 BP >140/90: Two from different classes: preferably RAS-inhibitor (ACEI or ARB) with either thiazide diuretic/thiazide-like diuretic or dihydropyridine CCB. ESH 2023 [3] General age <65 General age 65–79 General age ≥80 <130/80 <140 SBP <150 SBP
DOC has blood-pressure raising effects similar to aldosterone, and abnormally high levels result in hypokalemic hypertension. [ 39 ] 11β-hydroxylase deficiency , aka apparent mineralocorticoid excess syndrome , involves a defect in the gene for 11β-hydroxysteroid dehydrogenase , an enzyme that normally inactivates circulating cortisol to the ...