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Phytomenadione, also known as vitamin K 1 or phylloquinone, is a vitamin found in food and used as a dietary supplement. [6] [7] It is on the World Health Organization's List of Essential Medicines. [8] It is used to treat certain bleeding disorders, [7] including warfarin overdose, vitamin K deficiency, and obstructive jaundice. [7]
Vitamin K is a family of structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. [1] The human body requires vitamin K for post-synthesis modification of certain proteins that are required for blood coagulation ("K" from Danish koagulation, for "coagulation") or for controlling binding of calcium in bones and other tissues. [2]
In 1929, Henrik Dam discovered Vitamin K, also known as phylloquinone, phytonadione, or phytomenadione, which is a fat-soluble vitamin. Vitamin K is a family of structures of the aforementioned molecules and is not a single compound.
Treatment of established bleeding depends on the location but includes vitamin K 1 (phylloquinone; phytomenadione; phytonadione) administration which restores the prothrombin time rapidly. Severe bleeding may require blood products such as fresh frozen plasma (FFP), a prothrombin complex concentrate (PCC).
The menadione core is apparent in the structure of vitamin K.. It is an intermediate in the chemical synthesis of vitamin K by first reduction to the diol menadiol, which is susceptible to coupling to the phytol. [10]
Phytomenadione, also known as phylloquinone or Vitamin K 1 This page was last edited on 26 December 2021, at 21:21 (UTC). Text is available under the Creative ...
2-Methylnaphthalene-1,4-diamine is a synthetic menadione analog with vitamin K activity. [3] [2]2-Methylnaphthalene-1,4-diamine was first synthesized in 1925. [1] [3] In 1942 two different research groups noted the vitamin K activity of the compound.
Menadiol is an organic compound with the formula C 6 H 4 (COH) 2 (CH)(CH 3).It is formally a derivative of p-hydroquinone.The name vitamin K 4 can refer to: . specifically this compound, [1] [2]