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Other rheumatological disorders that can cause the features typical for RS3PE include late onset (seronegative) rheumatoid arthritis, acute sarcoidosis, ankylosing spondylitis and other spondyloarthropathies such as psoriatic arthropathy, mixed connective tissue disease, chondrocalcinosis and arthropathy due to amyloidosis. [6] [9]
Rheumatoid arthritis; A hand severely affected by rheumatoid arthritis. This degree of swelling and deformation does not typically occur with current treatment. Specialty: Rheumatology, Immunology: Symptoms: Warm, swollen, painful joints [1] Complications: Low red blood cells, inflammation around the lungs, inflammation around the heart [1 ...
Researchers have investigated the effects of autoantibody serostatus on autoimmune disease presentation. [2] [3] [4] Study of seronegative patient populations has led to the identification of additional autoantibodies that could potentially help with diagnosis. [5] [6]
Axial spondyloarthritis (also often referred to as axSpA) is a chronic, immune-mediated disease predominantly affecting the axial skeleton (sacroiliac joints and spine). [1] The term itself is an umbrella term characterizing a diverse disease family united by shared clinical and genetic features, such as the involvement of the axial skeleton. [2]
In antisynthetase syndrome, arthritis is commonly described as a symmetrical, non-erosive polyarthritis of the small hands and feet that can sometimes mimic CTD-associated, rheumatoid, and seronegative inflammatory arthritis. [21] Arthritis is non-specific and occurs in about 18–55% of Idiopathic inflammatory myopathies. [21]
Dactylitis can occur in seronegative arthropathies, such as psoriatic arthritis and ankylosing spondylitis, and in sickle-cell disease as result of a vasoocclusive crisis with bone infarcts, and in infectious conditions including tuberculosis, syphilis, and leprosy. In reactive arthritis, sausage fingers occur due to synovitis. [2]
Distal joints are frequently impacted by psoriatic arthritis, which is typically asymmetrical. [10] Up to 20% of people with inflammatory bowel disease (IBD) develop spondyloarthropathy. Those with Crohn's disease are more likely to have this association than those with ulcerative colitis. Arthritis may appear before clinical bowel disease.
Psoriatic arthritis (PsA) is a long-term inflammatory arthritis that occurs in people affected by the autoimmune disease psoriasis. [ 1 ] [ 2 ] The classic features of psoriatic arthritis include dactylitis (sausage-like appearance), skin lesions, and nail lesions. [ 3 ]
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