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Individual differences also arise among people in terms of age, weight, gender, health status, etc. [20] Thus, in most circumstances, the threshold dose serves as a reference to evaluate the probable outcome of a certain dosage of a substance for the general population, while great deviations might exist in special populations such as ...
In determining bioequivalence between two products such as a commercially available Branded product and a potential to-be-marketed Generic product, pharmacokinetic studies are conducted whereby each of the preparations are administered in a cross-over study (sometimes parallel study, when a cross-over study is not feasible) to volunteer subjects, generally healthy individuals but occasionally ...
Stochastic health effects are those that occur by chance, and whose probability is proportional to the dose, but whose severity is independent of the dose. [3] The LNT model assumes there is no lower threshold at which stochastic effects start, and assumes a linear relationship between dose and the stochastic health risk.
The effects can include those manifested within animals (including humans), microorganisms, or combinations of organisms (for example, infection). Pharmacodynamics and pharmacokinetics are the main branches of pharmacology , being itself a topic of biology interested in the study of the interactions of both endogenous and exogenous chemical ...
The Hill equation can be used to describe dose–response relationships, for example ion channel-open-probability vs. ligand concentration. [9] Dose is usually in milligrams, micrograms, or grams per kilogram of body-weight for oral exposures or milligrams per cubic meter of ambient air for inhalation exposures. Other dose units include moles ...
In clinical pharmacology, dose refers to the amount of drug administered to a person, and dosage is a fuller description that includes not only the dose (e.g., "500 mg") but also the frequency and duration of the treatment (e.g., "twice a day for one week").
Dosage typically includes information on the number of doses, intervals between administrations, and the overall treatment period. [3] For example, a dosage might be described as "200 mg twice daily for two weeks," where 200 mg represents the individual dose, twice daily indicates the frequency, and two weeks specifies the duration of treatment.
For example, to cause gastrointestinal disorders, the food must contain more than 100,000 Salmonella per gram or 1000 per gram for salmonellosis. [ 1 ] however, some viruses like DHBV( duck hepatitis B virus) need as low as 9.5 x 10(9) virus per milliliters to cause liver infections [ 2 ] .To know the dose ingested, it is also necessary to know ...