Search results
Results from the WOW.Com Content Network
All pathogens have an infectious dose typically given in number of cells. The infectious dose varies by organism and can be dependent on the specific type of strain. [21] Some pathogens can infect a host with only a few cells, while others require millions or billions. Examples of infectious doses, ranked loosely in increasing order: [22]
In determining bioequivalence between two products such as a commercially available Branded product and a potential to-be-marketed Generic product, pharmacokinetic studies are conducted whereby each of the preparations are administered in a cross-over study (sometimes parallel study, when a cross-over study is not feasible) to volunteer subjects, generally healthy individuals but occasionally ...
So, the bactericidal activity of a particular disinfectant at a given concentration can be expressed as a constant (k) calculated by employing the formula k = N/C·T where N is the number of surviving cells, C is the concentration of agent applied and T is the time for which the agent is applied, so k is inversely proportional to dose (C·T is ...
The effects can include those manifested within animals (including humans), microorganisms, or combinations of organisms (for example, infection). Pharmacodynamics and pharmacokinetics are the main branches of pharmacology , being itself a topic of biology interested in the study of the interactions of both endogenous and exogenous chemical ...
Threshold dose is the minimum dose of drug that triggers minimal detectable biological effect in an animal. [1] At extremely low doses, biological responses are absent for some of the drugs. The increase in dose above threshold dose induces an increase in the percentage of biological responses. [ 2 ]
The dose-response relationship for a given effect (e.g., diarrhea) is therefore the relationship between the dose and the likelihood of experiencing this effect. When the response is less than about 10%, it is observed that there is a strictly proportional relationship between dose and response:
The dose–response relationship, or exposure–response relationship, describes the magnitude of the response of an organism, as a function of exposure (or doses) to a stimulus or stressor (usually a chemical) after a certain exposure time. [1] Dose–response relationships can be described by dose–response curves. This is explained further ...
Thus for example, an absorbed dose of 1 Gy by alpha particles will lead to an equivalent dose of 20 Sv, and an equivalent dose of radiation is estimated to have the same biological effect as an equal amount of absorbed dose of gamma rays, which is given a weighting factor of 1. To obtain the equivalent dose for a mix of radiation types and ...