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English: Depiction of the various key subsets of CD4-positive T cells with corresponding associated cytokines and transcription factors. Figure legend T cells leave the thymus in a naïve, antigen non-experiened state. After contact with antigen, T cells may take on one of numerous subsets.
In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). CD4 is found on the surface of immune cells such as helper T cells , monocytes , macrophages , and dendritic cells .
The T helper cells (T h cells), also known as CD4 + cells or CD4-positive cells, are a type of T cell that play an important role in the adaptive immune system. They aid the activity of other immune cells by releasing cytokines .
T cells are grouped into a series of subsets based on their function. CD4 and CD8 T cells are selected in the thymus, but undergo further differentiation in the periphery to specialized cells which have different functions. T cell subsets were initially defined by function, but also have associated gene or protein expression patterns.
T helper cell 22, also known as the Th22 cell, are a type of immune cell. Th22 are a derivative of naïve CD4+ T cells induced by the ligand activation of the transcription factor aryl hydrocarbon receptor (AhR), [1] which uses environmental, metabolic, microbial, and dietary cues to control complex transcriptional programmes. [2] Th22 cell’s ...
T-cell surface glycoprotein CD1e is a protein in humans encoded by the CD1E gene. CD2: a type I transmembrane protein found on thymocytes, T cells, and some natural killer cells that acts as a ligand for CD58 and CD59 and is involved in signal transduction and cell adhesion; expressed in T-cell acute lymphoblastic leukemia and T-cell lymphoma. CD3*
Th22 cells (T helper cells type 22) are subpopulation of CD4+ T cells that produce interleukin-22 . They play a role in the protective mechanisms against variety of bacterial pathogens, tissue repair and wound healing, and also in pathologic processes, including inflammations , autoimmunity , tumors, and digestive organs damages.
All T cells derive from progenitor cells in the bone marrow, which become committed to their lineage in the thymus.All T cells begin as CD4-CD8-TCR- cells at the DN (double-negative) stage, where an individual cell will rearrange its T cell receptor genes to form a unique, functional molecule, which they, in turn, test against cells in the thymic cortex for a minimal level of interaction with ...