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Common side effects of antidepressant switching or discontinuation include: Returning symptoms of depression. Suicidal thoughts. Serotonin syndrome. Irritability. Flu-like symptoms. Dizziness.
If you currently use an SSRI, you’re not alone — SSRIs and other antidepressants are so common that between 2015 and 2018, over 13 percent of adults used an antidepressant. There’s no shame ...
Two or more antidepressants taken together, from either the same or different classes (affecting the same area of the brain, often at a much higher level). An antipsychotic combined with an antidepressant, particularly atypical antipsychotics such as aripiprazole (Abilify), quetiapine (Seroquel), olanzapine (Zyprexa), and risperidone (Risperdal).
In adults and children with bipolar disorder, SSRIs may cause a bipolar switch from depression into hypomania/mania, mixed states or rapid cycling. [159] When taken with mood stabilizers , the risk of switching is not increased, however when taking SSRIs as a monotherapy , the risk of switching may be twice or three times that of the average.
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However, there are differences between TCA related antidepressants and classical TCAs in terms of side effect profiles and withdrawal when compared to SSRIs. [67] There is evidence a prominent side-effect of antidepressants, emotional blunting, is confused with a symptom of depression itself. The cited study, according to Professor Linda Gask was:
This translates to the 2nd- and 3rd-most-common antidepressants, behind Lexapro (escitalopram), an SSRI. [88] In some studies, SNRIs demonstrated slightly higher antidepressant efficacy than the SSRIs (response rates 63.6% versus 59.3%). [43] However, in one study escitalopram had a superior efficacy profile to venlafaxine. [89]
Among the patients who were switched to a different antidepressant, there was no significant difference among the different antidepressants. For level three, the remission rates based on the HAM-D symptom scale were 12.3% for mirtazapine and 19.8% for nortriptyline, although the difference was not large enough for statistical significance. [5]
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