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Neurogenic bowel dysfunction (NBD) is reduced ability or inability to control defecation due to deterioration of or injury to the nervous system, resulting in fecal incontinence or constipation. [1] It is common in people with spinal cord injury (SCI), multiple sclerosis (MS) or spina bifida .
Fecal impaction is a common result of neurogenic bowel dysfunction and causes immense discomfort and pain. Its treatment includes laxatives, enemas, and pulsed irrigation evacuation (PIE) as well as digital removal. It is not a condition that resolves without direct treatment.
353.2 Cervical root lesions, not elsewhere classified; 353.3 Thoracic root lesions, not elsewhere classified; 353.4 Lumbosacral root lesions, not elsewhere classified; 353.5 Neuralgic amyotrophy; 353.6 Phantom limb syndrome; 353.8 Other; 353.9 Unspecified; 354 Mononeuritis of upper limb and mononeuritis multiplex. 354.0 Carpal tunnel syndrome ...
FGIDs share in common any of several physiological features including increased motor reactivity, enhanced visceral hypersensitivity, altered mucosal immune and inflammatory function (associated with bacterial dysbiosis), and altered central nervous system and enteric nervous system (CNS-ENS) regulation.
Anismus is classified as a functional defecation disorder. It is also a type of rectal outlet obstruction (a functional outlet obstruction). Where anismus causes constipation, it is an example of functional constipation. Many authors describe an "obstructed defecation syndrome", of which anismus is a cause. [24]
Not essential in humans, but essential/beneficial for some non-human eucarya Main articles: Mineral (nutrient) and Composition of the human body Dietary minerals are inorganic chemical elements required by living organisms, [ 64 ] other than the four elements carbon , hydrogen , nitrogen , and oxygen that are present in nearly all organic ...
Outlet obstruction is a sub-type of large bowel obstruction and refers to conditions affecting the anorectal region that obstruct defecation, specifically conditions of the pelvic floor and anal sphincters. Outlet obstruction can be classified into four groups. [24] Functional outlet obstruction Inefficient inhibition of the internal anal sphincter
One way in which intestinal permeability is modulated is via CXCR3 receptors in cells in the intestinal epithelium, which respond to zonulin. [4]Gliadin (a glycoprotein present in wheat) activates zonulin signaling in all people who eat gluten, irrespective of the genetic expression of autoimmunity.