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Oncogenomics is a sub-field of genomics that characterizes cancer-associated genes.It focuses on genomic, epigenomic and transcript alterations in cancer. Cancer is a genetic disease caused by accumulation of DNA mutations and epigenetic alterations leading to unrestrained cell proliferation and neoplasm formation.
Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells. The process is characterized by changes at the cellular, genetic , and epigenetic levels and abnormal cell division .
Gene expression profiling is a technique used in molecular biology to query the expression of thousands of genes simultaneously. While almost all cells in an organism contain the entire genome of the organism, only a small subset of those genes is expressed as messenger RNA (mRNA) at any given time, and their relative expression can be evaluated.
A proto-oncogene is a normal gene that could become an oncogene due to mutations or increased expression.Proto-oncogenes code for proteins that help to regulate the cell growth and differentiation.
Oncometabolism is the field of study that focuses on the metabolic changes that occur in cells that make up the tumor microenvironment (TME) and accompany oncogenesis and tumor progression toward a neoplastic state. [1] Cells with increased growth and survivability differ from non-tumorigenic cells in terms of metabolism. [2]
Using the Cancer Intervention and Surveillance Modeling Network (CISNET) and cancer mortality data, the study analyzed death rates and screenings for five cancer types: breast, cervical ...
Illustration of how a normal cell is converted to a cancer cell, when an oncogene becomes activated.. A direct oncogenic viral mechanism [11] involves either insertion of additional viral oncogenic genes into the host cell or to enhance already existing oncogenic genes (proto-oncogenes) in the genome.
Supreme Court Chief Justice John Roberts slammed what he described as “dangerous” talk by some officials about ignoring federal court rulings, using an annual report weeks before President ...
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