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Several skin whitening agents, including tyrosinase inhibitors, have been found to cause an increase in the expression of tyrosinase, which by itself would increase melanin synthesis. [ 43 ] Microphthalmia-associated transcription factor (MITF) is the master transcription factor that controls the expression of TYR, TRP1, and TRP2, MART1 ...
The body undergoes many hormonal changes during menopause, which can trigger increased melanin production and increased hyperpigmentation in the skin, in addition to everything else, according to ...
White women may have darker skin than white men because the female sex hormone estrogen is known to increase skin pigmentation in lighter-skinned populations. [12] White women's skin is significantly darker than White men's, to the extent that White women have a much lower rate of skin cancer than White men. [12]
Natural bronzers use natural ingredients, such as caramel, riboflavin, etc. These ingredients provide a slight instant boost of color, but will wash off in the shower. Higher quality natural bronzer lotions will have certain organic ingredients/natural or exotic extracts that aid in the process of tanning (melanin production/oxidization).
However, some studies show that melanin — another genetically inherited substance in the skin — can help protect against sun-induced aging. Darker skin tones contain more melanin than lighter ...
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Melanin protects the body by absorbing ultraviolet radiation. Excessive UV radiation causes sunburn along with other direct and indirect DNA damage to the skin, and the body naturally combats and seeks to repair the damage and protect the skin by creating and releasing further melanin into the skin's cells. With the production of the melanin ...
Bremelanotide, another analogue of α-MSH, is available in the United States not as a photoprotective agent, but for the treatment of hypoactive sexual desire disorder in premenopausal women. [4] All of these drugs have significantly greater potencies than α-MSH, along with improved pharmacokinetics and distinctive selectivity profiles.