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Pulmonary surfactant is a surface-active complex of phospholipids and ... identified the function of the pulmonary surfactant in increasing the compliance of the ...
In molecular biology, Pulmonary surfactant protein D (SP-D) is a protein domain predominantly found in lung surfactant. This protein plays a special role; its primary task is to act as a defence protein against any pathogens that may invade the lung. It also plays a role in lubricating the lung and preventing it from collapse.
SP-B is a critical protein for lung function, and is found in the context of pulmonary surfactant. Understanding surfactant is important to gaining a full understanding of SP-B. Surfactant is a mixture of lipids and proteins that coats the inside of alveoli and is essential for life due to its key role in preventing alveolar collapse at low ...
The protein component of surfactant helps in the modulation of the innate immune response, and inflammatory processes. Alveolar sac region of the lung - TEM. SP-A1 is a member of a subfamily of C-type lectins called collectins. Together with SP-A2, they are the most abundant proteins of pulmonary surfactant.
20390 Ensembl ENSG00000133661 ENSMUSG00000021795 UniProt P35247 P50404 RefSeq (mRNA) NM_003019 NM_009160 RefSeq (protein) NP_003010 NP_033186 Location (UCSC) Chr 10: 79.94 – 79.98 Mb Chr 14: 40.89 – 40.91 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Surfactant protein D, also known as SP-D, is a lung surfactant protein part of the collagenous family of lectins called collectin ...
Dipalmitoylphosphatidylcholine (DPPC) is a phospholipid (and a lecithin) consisting of two C 16 palmitic acid groups attached to a phosphatidylcholine head-group.. It is the main constituent of pulmonary surfactants, which reduces the work of breathing and prevents alveolar collapse during breathing.
The protein component of surfactant helps in the modulation of the innate immune response, and inflammatory processes. [7] Alveolar sac region of the lung - TEM. SP-A2 is a member of a subfamily of C-type lectins called collectins. Together with (surfactant protein A1 ) SP-A1, they are the most abundant proteins of pulmonary surfactant.
These mutations cause total absence or loss-of-function of SP-B and lead to imbalance in surfactant homeostasis. Since SP-B has a major role in surfactant biogenesis and spreading of surfactant and lipid layer, any disruption to existence of SP-B results in ineffective respiration and lethal pulmonary conditions at birth. [5]