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The DNA repair transcriptomes of the liver of humans, naked mole-rats and mice were compared. [114] The maximum lifespans of humans, naked mole-rat, and mouse are respectively ~120, 30 and 3 years. The longer-lived species, humans and naked mole rats expressed DNA repair genes, including core genes in several DNA repair pathways, at a higher ...
Naked mole rats were found to have higher levels of superoxide dismutase, a reactive oxygen species clearing antioxidant. In addition, naked mole rats had higher levels of base excision repair, DNA damage response signaling, homologous recombination repair, mismatch repair, nucleotide excision repair, and non-homologous end joining. In fact ...
In 2009, she published research that showed the mole rat's cells expressed a gene called p16 which prevented tumours from developing. [6] As a result of their "pioneering research on the causes of cancer resistance in naked mole-rats," Gorbunova and Seluanov won the 2009 Cozzarelli Prize. [ 7 ]
In 2018, naked mole-rats were identified as the first mammal to defy the Gompertz–Makeham law of mortality, and achieve negligible senescence. It has been speculated, however, that this may be simply a "time-stretching" effect primarily due to their very slow (and cold-blooded and hypoxic) metabolism. [6] [7] [8]
The Golan Heights blind mole-rat (Spalax golani) and the Judean Mountains blind mole-rat (Spalax judaei) are also resistant to cancer, but by a different mechanism. [ 35 ] In July 2023 a study reported the transference of the gene responsible for HMW-HA from a naked mole rat to mice leading to improved health and an approximate 4.4 percent ...
The maximum life spans of mice, naked mole-rats and humans are respectively ~3, ~30 and ~129 years. [65] Of these, the shortest lived species, mouse, expresses DNA repair genes, including core genes in several DNA repair pathways, at a lower level than do humans and naked mole rats. [ 65 ]
Gene Annotator: The Gene Annotator or GA tool takes as input a list of gene symbols, RGD IDs, GenBank accession numbers, Ensembl identifiers, or a chromosomal region and retrieves gene orthologs, external database identifiers and ontology annotations for the corresponding genes in RGD. The data can be downloaded into an Excel spreadsheet or ...
Rochelle Buffenstein is an American comparative biologist currently working as Research Professor at the University of Illinois Chicago.Previously, she was a senior principal investigator at Calico Life Sciences, an Alphabet, Inc. funded research and development company investigating the biology that controls aging and lifespan where she used the extraordinarily long-lived cancer resistant ...