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Bromazepam, sold under many brand names, is a benzodiazepine. It is mainly an anti-anxiety agent with similar side effects to diazepam. In addition to being used to treat anxiety or panic states, bromazepam may be used as a premedicant prior to minor surgery. Bromazepam typically comes in doses of 3 mg and 6 mg tablets. [4]
[23] [30] If planning to conceive while using contraindicated medications, a washout and waiting period before conception is advised. [24] A herbal product, vitex agnus-castus should not be used during gestation due to undesirable hormonal effects. [32] Safety data supports the use of blue and red light therapy as non-drug treatments to consider.
There is controversy concerning the safety of benzodiazepines in pregnancy. While they are not major teratogens , uncertainty remains as to whether they cause cleft palate in a small number of babies and whether neurobehavioural effects occur as a result of prenatal exposure; [ 18 ] they are known to cause withdrawal symptoms in the newborn .
The tables below contain a sample list of benzodiazepines and benzodiazepine analogs that are commonly prescribed, with their basic pharmacological characteristics, such as half-life and equivalent doses to other benzodiazepines, also listed, along with their trade names and primary uses.
Contraindicated in pregnancy: Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
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Concerns regarding whether benzodiazepines during pregnancy cause major malformations, in particular cleft palate, have been hotly debated in the literature. A meta analysis of the data from cohort studies found no link but meta analysis of case–control studies did find a significant increase in major malformations. (However, the cohort ...
Andalusia had a normal pregnancy, only noticing that Caper would move in her stomach at odd times. She had to be induced because her son was past his due date but didn’t think anything of it ...