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Mitochondrial DNA is the small circular chromosome found inside mitochondria. These organelles, found in all eukaryotic cells, are the powerhouse of the cell. [1] The mitochondria, and thus mitochondrial DNA, are passed exclusively from mother to offspring through the egg cell.
A mitochondrion (pl. mitochondria) is an organelle found in the cells of most eukaryotes, such as animals, plants and fungi. Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is used throughout the cell as a source of chemical energy. [2]
Nuclear DNA and mitochondrial DNA differ in many ways, starting with location and structure. Nuclear DNA is located within the nucleus of eukaryote cells and usually has two copies per cell while mitochondrial DNA is located in the mitochondria and contains 100–1,000 copies per cell.
The nucleus is spherical and separated from the cytoplasm by a double membrane called the nuclear envelope, space between these two membrane is called perinuclear space. The nuclear envelope isolates and protects a cell's DNA from various molecules that could accidentally damage its structure or interfere with its processing.
The size of the nucleus is correlated to the size of the cell, and this ratio is reported across a range of cell types and species. [9] In eukaryotes the nucleus in many cells typically occupies 10% of the cell volume. [10]: 178 The nucleus is the largest organelle in animal cells.
NUMT insertion into the nuclear genome and its persistence in the nuclear genome is initiated by the physical delivery of mitochondrial DNA to the nucleus. [5] This step follows by the mtDNA integration into the genome through a non-homologous end joining mechanism during the double-strand break (DSB) repair process as envisioned by studying Saccharomyces cerevisiae, [13] [29] and terminates ...
Nucleus: The nucleus of the cell functions as the genome and genetic information storage for the cell, containing all the DNA organized in the form of chromosomes. It is surrounded by a nuclear envelope, which includes nuclear pores allowing for the transportation of proteins between the inside and outside of the nucleus. [15]
The division between prokaryotes and eukaryotes reflects two very different levels of cellular organization; only eukaryotic cells have an enclosed nucleus that contains its DNA, and other membrane-bound organelles including mitochondria.