Search results
Results from the WOW.Com Content Network
The naked mole rat has a disproportionately long life of 30 years through efficient cellular repair mechanisms. There are numerous studies that support cellular damage, often due to a lack of somatic maintenance mechanisms, as a primary determinant for aging, and these studies have given rise to the free radical theory of aging and the DNA ...
In 2018, naked mole-rats were identified as the first mammal to defy the Gompertz–Makeham law of mortality, and achieve negligible senescence. It has been speculated, however, that this may be simply a "time-stretching" effect primarily due to their very slow (and cold-blooded and hypoxic) metabolism. [6] [7] [8]
The DNA repair transcriptomes of the liver of humans, naked mole-rats and mice were compared. [114] The maximum lifespans of humans, naked mole-rat, and mouse are respectively ~120, 30 and 3 years. The longer-lived species, humans and naked mole rats expressed DNA repair genes, including core genes in several DNA repair pathways, at a higher ...
The Golan Heights blind mole-rat (Spalax golani) and the Judean Mountains blind mole-rat (Spalax judaei) are also resistant to cancer, but by a different mechanism. [ 35 ] In July 2023 a study reported the transference of the gene responsible for HMW-HA from a naked mole rat to mice leading to improved health and an approximate 4.4 percent ...
Mutations is genetic information that are expressed among organisms via gene expression, which is the translation of genetic information into a phenotypic character. [14] Evolution is the change in a heritable trait in a population across generations since mutations generate variations in the heritable traits; they are considered the raw ...
However, some mutations that increase ROS production (e.g., by reducing antioxidant defenses) in worms increase, rather than decrease, their longevity. [72] Also, naked mole rats, rodents about the size of mice, live about eight times longer than mice despite having reduced, compared to mice, antioxidant defenses and increased oxidative damage ...
Biological immortality (sometimes referred to as bio-indefinite mortality) is a state in which the rate of mortality from senescence (or aging) is stable or decreasing, thus decoupling it from chronological age.
In 2009, she published research that showed the mole rat's cells expressed a gene called p16 which prevented tumours from developing. [6] As a result of their "pioneering research on the causes of cancer resistance in naked mole-rats," Gorbunova and Seluanov won the 2009 Cozzarelli Prize. [ 7 ]