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However, although these naked mole rats are mammalian, they are highly atypical in terms of aging studies and may not serve as the best model for humans. For example, naked mole rats have a disproportionately high longevity quotient and live in eusocial societies, where breeding is usually designated to a queen. [46]
The DNA repair transcriptomes of the liver of humans, naked mole-rats and mice were compared. [114] The maximum lifespans of humans, naked mole-rat, and mouse are respectively ~120, 30 and 3 years. The longer-lived species, humans and naked mole rats expressed DNA repair genes, including core genes in several DNA repair pathways, at a higher ...
In 2018, naked mole-rats were identified as the first mammal to defy the Gompertz–Makeham law of mortality, and achieve negligible senescence. It has been speculated, however, that this may be simply a "time-stretching" effect primarily due to their very slow (and cold-blooded and hypoxic) metabolism. [6] [7] [8]
Mutations is genetic information that are expressed among organisms via gene expression, which is the translation of genetic information into a phenotypic character. [14] Evolution is the change in a heritable trait in a population across generations since mutations generate variations in the heritable traits; they are considered the raw ...
The Golan Heights blind mole-rat (Spalax golani) and the Judean Mountains blind mole-rat (Spalax judaei) are also resistant to cancer, but by a different mechanism. [ 35 ] In July 2023 a study reported the transference of the gene responsible for HMW-HA from a naked mole rat to mice leading to improved health and an approximate 4.4 percent ...
The maximum life spans of mice, naked mole-rats and humans are respectively ~3, ~30 and ~129 years. [65] Of these, the shortest lived species, mouse, expresses DNA repair genes, including core genes in several DNA repair pathways, at a lower level than do humans and naked mole rats. [ 65 ]
The Rat Genome Database (RGD) is a database of rat genomics, genetics, physiology and functional data, as well as data for comparative genomics between rat, human and mouse. [1] [2] RGD is responsible for attaching biological information to the rat genome via structured vocabulary, or ontology, annotations assigned to genes and quantitative ...
Rochelle Buffenstein is an American comparative biologist currently working as Research Professor at the University of Illinois Chicago.Previously, she was a senior principal investigator at Calico Life Sciences, an Alphabet, Inc. funded research and development company investigating the biology that controls aging and lifespan where she used the extraordinarily long-lived cancer resistant ...