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The birth defects caused by the drug thalidomide can range from moderate malformation to more severe forms. Possible birth defects include phocomelia, dysmelia, amelia, bone hypoplasticity, and other congenital defects affecting the ear, heart, or internal organs. [41]
The birth defects caused by thalidomide led to the development of greater drug regulation and monitoring in many countries. [9] [11] It was approved in the United States in 1998 for use as a treatment for cancer. [6] It is on the World Health Organization's List of Essential Medicines. [12] It is available as a generic medication. [8] [13]
Kelsey's insistence that the drug should be fully tested prior to approval was vindicated in November 1961 when the births of deformed infants in Europe were linked to thalidomide ingestion by their mothers during pregnancy. [14] [15] Researchers discovered that the thalidomide crossed the placental barrier and caused serious birth defects. [9]
Thalidomide, also sold under the brand names Contergan and Distaval, was available in 46 countries and caused birth defects, stillbirths and miscarriages. ... “Thalidomide’s a drug that just ...
Hagens Berman: U.S. Judge Rejects Pharmaceutical Companies' Attempt to Dismiss Thalidomide Cases Judge rejects defendants' statute of limitations argument at this stage of litigation SEATTLE ...
‘The thalidomide tragedy is a dark chapter in the history of our nation and the world’ Australia to issue national apology to citizens affected by ‘Thalidomide birth defects’ Skip to main ...
McBride published a letter in The Lancet, in December 1961, noting a large number of birth defects in children of patients who were prescribed thalidomide, [9] after a midwife named Sister Pat Sparrow first suspected the drug was causing birth defects in the babies of patients under his care at Crown Street Women's Hospital in Sydney. [10]
In 1970, about 10 years after thalidomide was withdrawn from sale, McCredie was asked whether X-rays could help determine who were true thalidomide victims entitled to compensation from the manufacturer. During her investigations, she observed the way in which thalidomide caused malformations and also discovered a new mechanism of embryogenesis ...