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Bordetella parapertussis is a small Gram-negative bacterium of the genus Bordetella that is adapted to colonise the mammalian respiratory tract. [1] Pertussis caused by B. parapertussis manifests with similar symptoms to B. pertussis -derived disease, but in general tends to be less severe. [ 2 ]
Bordetella (/ ˌ b ɔːr d ə ˈ t ɛ l ə /) is a genus of small (0.2 – 0.7 μm), Gram-negative, coccobacilli bacteria of the phylum Pseudomonadota. Bordetella species, with the exception of B. petrii , are obligate aerobes , as well as highly fastidious , or difficult to culture.
Bordetella pertussis is a Gram-negative, aerobic, pathogenic, encapsulated coccobacillus bacterium of the genus Bordetella, and the causative agent of pertussis or whooping cough. Its virulence factors include pertussis toxin , adenylate cyclase toxin , filamentous haemagglutinin , pertactin , fimbria , and tracheal cytotoxin .
The respiratory illness is caused by a bacteria called bordetella pertussis that spreads easily from person to person, according to the CDC. When a person with pertussis sneezes or coughs, they ...
Pertussis toxin (PT) is a protein-based AB 5-type exotoxin produced by the bacterium Bordetella pertussis, [2] which causes whooping cough.PT is involved in the colonization of the respiratory tract and the establishment of infection. [3]
Adenylate cyclase toxin from Bordetella pertussis is a 1706 amino acid residue long protein.The protein consists of three domains: from the N-terminus up to roughly residue 400, there is an adenylate-cyclase domain; between residues 500 and 700, there is a hydrophobic domain; and from residue 1000 to the C-terminus, there are calcium binding repeats.
Tracheal cytotoxin (TCT) is a 921 dalton glycopeptide released by Bordetella pertussis, [1] Vibrio fischeri (as a symbiosis chemical), [2] and Neisseria gonorrhoeae (among other peptidoglycan-derived cytotoxins it produces). [3]
Bordet–Gengou agar is a type of agar plate optimized to isolate Bordetella, containing blood, potato extract, and glycerol, with an antibiotic such as cephalexin or penicillin and sometimes nicotinamide. [1]
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