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InterPro is a database of protein families, protein domains and functional sites in which identifiable features found in known proteins can be applied to new protein sequences [2] in order to functionally characterise them.
Pfam was founded in 1995 by Erik Sonnhammer, Sean Eddy and Richard Durbin as a collection of commonly occurring protein domains that could be used to annotate the protein coding genes of multicellular animals. [6] One of its major aims at inception was to aid in the annotation of the C. elegans genome. [6]
Interferon regulatory factors (IRF) are proteins which regulate transcription of interferons (see regulation of gene expression). [1] Interferon regulatory factors contain a conserved N-terminal region of about 120 amino acids, which folds into a structure that binds specifically to the IRF-element (IRF-E) motifs, which is located upstream of the interferon genes. [2]
Stockholm format is a multiple sequence alignment format used by Pfam, Rfam and Dfam, to disseminate protein, RNA and DNA sequence alignments. [1] [2] [3] The alignment editors Ralee, [4] Belvu and Jalview support Stockholm format as do the probabilistic database search tools, Infernal and HMMER, and the phylogenetic analysis tool Xrate.
[1] [2] Butyrophilin (Btn) genes constitute a subgroup of at least 10 genes in the Ig superfamily identified in human, mouse, cow, goat and other species. [ 3 ] The eponymous Btn gene (BTN1A1 in humans; Btn1a1 in mouse) is highly expressed in the secretory epithelium of the mammary gland during lactation.
Feline eyes also contain the same color-sensing cones as humans, but this doesn't mean our visions are the same, VCA Animal Hospitals reports. Cats are limited in their perception of color.
A large group of two component regulator proteins appear to have the same N-terminal structure of 14 tandem repeats.These repeats show homology to members of INTERPRO and INTERPRO indicating that they are likely to form a beta-propeller.
G 12 /G 13 alpha subunits are alpha subunits of heterotrimeric G proteins that link cell surface G protein-coupled receptors primarily to guanine nucleotide exchange factors for the Rho small GTPases to regulate the actin cytoskeleton. [1] Together, these two proteins comprise one of the four classes of G protein alpha subunits. [2]