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InterPro is a database of protein families, protein domains and functional sites in which identifiable features found in known proteins can be applied to new protein sequences [2] in order to functionally characterise them.
The general purpose of the Pfam database is to provide a complete and accurate classification of protein families and domains. [5] Originally, the rationale behind creating the database was to have a semi-automated method of curating information on known protein families to improve the efficiency of annotating genomes. [6]
The profile-HMM implementation used in the HMMER software was based on the work of Krogh and colleagues. [3] HMMER is a console utility ported to every major operating system, including different versions of Linux, Windows, and macOS. HMMER is the core utility that protein family databases such as Pfam and InterPro are based upon.
These proteins contain between 1 and 7 Kazal-type inhibitor repeats. [4] [5] The structure of the Kazal repeat includes a large quantity of extended chain, 2 short alpha-helices and a 3-stranded anti-parallel beta sheet. [4] The inhibitor makes 11 contacts with its enzyme substrate: unusually, 8 of these important residues are hypervariable. [5]
Stockholm format is a multiple sequence alignment format used by Pfam, Rfam and Dfam, to disseminate protein, RNA and DNA sequence alignments. [1] [2] [3] The alignment editors Ralee, [4] Belvu and Jalview support Stockholm format as do the probabilistic database search tools, Infernal and HMMER, and the phylogenetic analysis tool Xrate.
A large group of two component regulator proteins appear to have the same N-terminal structure of 14 tandem repeats.These repeats show homology to members of INTERPRO and INTERPRO indicating that they are likely to form a beta-propeller.
This article incorporates text from the public domain Pfam and InterPro: IPR000472 This transmembrane receptor -related article is a stub . You can help Wikipedia by expanding it .
G 12 /G 13 alpha subunits are alpha subunits of heterotrimeric G proteins that link cell surface G protein-coupled receptors primarily to guanine nucleotide exchange factors for the Rho small GTPases to regulate the actin cytoskeleton. [1] Together, these two proteins comprise one of the four classes of G protein alpha subunits. [2]