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Interferon regulatory factor 8 (IRF8) also known as interferon consensus sequence-binding protein (ICSBP), is a protein that in humans is encoded by the IRF8 gene. [5] [6] [7] IRF8 is a transcription factor that plays critical roles in the regulation of lineage commitment and in myeloid cell maturation including the decision for a common myeloid progenitor (CMP) to differentiate into a ...
Interferon regulatory factors (IRF) are proteins which regulate transcription of interferons (see regulation of gene expression). [1] Interferon regulatory factors contain a conserved N-terminal region of about 120 amino acids, which folds into a structure that binds specifically to the IRF-element (IRF-E) motifs, which is located upstream of the interferon genes. [2]
Keiko Ozato is a Japanese American geneticist whose research has focused on gene regulation in the developing immune system; [1] She is best known for her contributions to immunogenetics and epigenetics in isolating the IRF8 transcription factor that aids humans in fighting off disease and for identifying the BRD4 protein that regulates cellular and viral genes that can invoke epigenetic memory.
Plant-based protein can help you hit your goals if you eat a variety to consume all of the essential amino acids. Experts share 10 best plant-based sources.
Some of the best plant-based sources of protein include tofu, tempeh, edamame, and a combination of rice and beans.
Inferred motif from similar protein – In vivo/Misc source : CACGTGAY MXD3: ENSG00000213347: bHLH: Inferred motif from similar protein – In vivo/Misc source : CACGTGAY MXD4: ENSG00000123933: bHLH: Inferred motif from similar protein – In vivo/Misc source : CACGTGAY MXI1: ENSG00000119950: bHLH: Known motif – In vivo/Misc source : CCACGTGG MYB
IRF4 is a transcription factor belonging to the Interferon Regulatory Factor (IRF) family of transcription factors. [8] [9] In contrast to some other IRF family members, IRF4 expression is not initiated by interferons; rather, IRF4 expression is promoted by a variety of bioactive stimuli, including antigen receptor engagement, lipopolysaccharide (LPS), IL-4, and CD40.
Type II cytokine receptors, also commonly known as class II cytokine receptors, are transmembrane proteins that are expressed on the surface of certain cells. They bind and respond to a select group of cytokines including interferon type I, interferon type II, interferon type III.
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