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Neonatal meningitis is a serious medical condition in infants that is rapidly fatal if untreated.Meningitis, an inflammation of the meninges, the protective membranes of the central nervous system, is more common in the neonatal period (infants less than 44 days old) than any other time in life, and is an important cause of morbidity and mortality globally.
Symptoms of Meningitis. Viral meningitis characteristically presents with fever, headache and neck stiffness. [9] Fever is the result of cytokines released that affect the thermoregulatory (temperature control) neurons of the hypothalamus. Cytokines and increased intracranial pressure stimulate nociceptors in the brain that lead to headaches.
Most forms of aseptic meningitis are viral in origin, though neoplastic and Lyme disease meningitis are also aseptic. California encephalitis virus; Central nervous system viral disease; Cytomegalovirus encephalitis; SARS-CoV-2; Eastern equine encephalitis; Enterovirus encephalitis; Epstein Barr Virus encephalitis; Herpes simplex encephalitis ...
Brudziński's sign or a Brudziński sign is any of three medical signs, all of which may occur in meningitis or meningism.All three are named after Józef Brudziński. [1] In English, the name is often written without the diacritic (like many borrowed words) (Brudzinski) and is pronounced / b r uː ˈ dʒ ɪ n s k i /.
Viral meningitis tends to run a more benign course than bacterial meningitis. Herpes simplex virus and varicella zoster virus may respond to treatment with antiviral drugs such as aciclovir , but there are no clinical trials that have specifically addressed whether this treatment is effective. [ 22 ]
Infants requiring intravascular catheters and other invasive procedures are at increased risk for developing LOS. [3] There are many etiologies of neonatal infection, including bacterial, viral and fungal pathogens. The source of infectious bacteria and other pathogens is often the maternal gastrointestinal and genitourinary tract.
Meningism is a set of symptoms similar to those of meningitis but not caused by meningitis. [1] [3] [4] Whereas meningitis is inflammation of the meninges (membranes that cover the central nervous system), meningism is caused by nonmeningitic irritation of the meninges, usually associated with acute febrile illness, [1] [2] especially in children and adolescents. [2]
Kernig's sign is a test used in physical examination to look for evidence of irritation of the meninges.The test involves flexing the thighs at the hip, and the knees, at 90 degree angles, and assessing whether subsequent extension of the knee is painful (leading to resistance), in which case it is deemed positive. [1]