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Retinyl palmitate, or vitamin A palmitate, is the ester of retinol and palmitic acid, with formula C 36 H 60 O 2. It is the most abundant form of vitamin A storage in animals. [2] An alternate spelling, retinol palmitate, which violates the -yl organic chemical naming convention for esters, is also frequently seen.
Retinal pigment epithelium-specific 65 kDa protein (also known as RPE65) is a retinoid isomerohydrolase enzyme of the vertebrate visual cycle. [5] [6] RPE65 is expressed in the retinal pigment epithelium (RPE, a layer of epithelial cells that nourish the photoreceptor cells) and is responsible for the conversion of all-trans-retinyl esters to 11-cis-retinol during phototransduction.
Retinol-binding proteins (RBP) are a family of proteins with diverse functions. They are carrier proteins that bind retinol.Assessment of retinol-binding protein is used to determine visceral protein mass in health-related nutritional studies.
Retinyl esters can be distinguished from retinol in serum and other tissues and quantified with the use of methods such as high-performance liquid chromatography. [21] Elevated amounts of retinyl ester (i.e., >10% of total circulating vitamin A) in the fasting state have been used as markers for chronic hypervitaminosis A in humans and monkeys ...
The major source of retinoids in human diet are plant pigments such as carotenes and retinyl esters derived from animal sources. [15] Retinyl esters are transported through the chylomicron pathway to the liver or fat tissue while retinol or carotenes are transported from the enterocytes to the liver and are processed into retinyl esters by LRAT ...
Dr. Shirazi says Retinyl Palmitate is the lightest and most gentle form of retinol. “I call it the chamomile tea version since it has to be converted three times to have an effect on the skin.
Retinoic acid (simplified nomenclature for all-trans-retinoic acid) is a metabolite of vitamin A 1 (all-trans-retinol) that is required for embryonic development, male fertility, regulation of bone growth and immune function. [2]
In enzymology, a retinyl-palmitate esterase (EC 3.1.1.21) is an enzyme that catalyzes the chemical reaction. retinyl palmitate + H 2 O ⇌ {\displaystyle \rightleftharpoons } retinol + palmitate Thus, the two substrates of this enzyme are retinyl palmitate and H 2 O , whereas its two products are retinol and palmitate .