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Trisomy 13 was first observed by Thomas Bartholin in 1657, [11] [12] but the chromosomal nature of the disease was ascertained by Dr. Klaus Patau and Dr. Eeva Therman in 1960. [13] The disease is named in Patau's honor. In England and Wales during 2008–09, there were 172 diagnoses of Patau syndrome (trisomy 13), with 91% of diagnoses made ...
Race is a categorization of humans based on shared physical or social qualities into groups generally viewed as distinct within a given society. [1] The term came into common usage during the 16th century, when it was used to refer to groups of various kinds, including those characterized by close kinship relations. [2]
This agonistic or antagonistic activity causes varied structural changes of the receptors, which results in activation or repression of the estrogen target genes. [3] [19] [4] [20] SERMs interact with receptors by diffusing into cells and their binding to ERα or ERβ subunits, which results in dimerization and structural changes of the ...
This is a list of dopaminergic drugs. These are pharmaceutical drugs , naturally occurring compounds and other chemicals that influence the function of the neurotransmitter dopamine . Receptor ligands
[24]: 189 In general, benzodiazepines are well tolerated and are safe and effective drugs in the short term for a wide range of conditions. [25] [26] Tolerance can develop to their effects and there is also a risk of dependence, and upon discontinuation a withdrawal syndrome may occur. These factors, combined with other possible secondary ...
A breakage and reunion in the pericentric region of the p arm results in a dicentric isochromosome. [4] Some of the p arm can be found in this formation of i(Xq), but a majority of the genetic material on the p arm is lost so it is considered absent.
Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
Many commonly used sedative and anxiolytic drugs that affect the GABA receptor complex are not agonists. These drugs act instead as positive allosteric modulators (PAMs) and while they do bind to the GABA receptors, they bind to an allosteric site on the receptor and cannot induce a response from the neuron without an actual agonist being present.