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Apixaban. Apixaban, sold under the brand name Eliquis, is an anticoagulant medication used to treat and prevent blood clots and to prevent stroke in people with nonvalvular atrial fibrillation through directly inhibiting factor Xa. [ 6][ 7][ 8] Specifically, it is used to prevent blood clots following hip or knee replacement and in those with a ...
Medical use. Direct factor Xa inhibitors include rivaroxaban, apixaban and edoxaban, and are types of direct oral anticoagulant (DOAC), which are blood thinning drugs, one of the classes of antithrombotic drugs. [ 4][ 5][ 6] They are commonly prescribed to treat and prevent blood clots in veins, prevent stroke and embolism in people with non ...
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Headache. Muscle pain. Chills. Nausea. Fever. But remember: “If you have side effects, they’re usually due to your immune system responding to the vaccine, which is how vaccines work,” says ...
Andexanet alfa is a biologic agent, a recombinant modified version of human activated factor X (FXa). [ 17] Andexanet alfa differs from native FXa due to the removal of a 34 residue fragment that contains the Gla domain. This modification reduces andexanet alfa's anticoagulant potential. Additionally, a serine to alanine (S419A) mutation in the ...
The decision is a blow to the companies as the drug faces slow take-up in the U.S. and underscores the complexities tied to a new class of drugs that have benefited early-stage patients, but could ...
When you have health insurance, Neffy will cost $25 for two single-use devices, says ARS Pharma, the company that makes Neffy. For people without health insurance, Neffy will cost $199 for two doses.
Rivaroxaban inhibits both free and bound Factor Xa in the prothrombinase complex. [33] It is a selective direct factor Xa inhibitor with an onset of action of 2.5 to 4 hours. [ 34 ] Inhibition of Factor Xa interrupts the intrinsic and extrinsic pathway of the blood coagulation cascade , inhibiting both thrombin formation and development of thrombi.
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