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In March 2022, the US FDA approved pembrolizumab for the treatment of advanced endometrial cancer. [36] In January 2023, the US FDA approved pembrolizumab for adjuvant treatment following resection and platinum-based chemotherapy for stage IB (T2a ≥ 4 cm), II, or IIIA non-small cell lung cancer. [37]
In July 2023, MSD and Moderna initiated the phase III study (study V940-001) evaluating mRNA-4157 in combination with pembrolizumab for adjuvant treatment of patients with resected high-risk stage IIB-stage IV melanoma.
For example, one immune check point inhibitor treatment, pembrolizumab, costs US$10,000 to $12,000 for a single dose administered every 3 weeks. [137] Cytokine therapies used for melanoma include IFN-a and IL-2. [138] IL-2 was the first new therapy approved (1990 EU, 1992 US) for the treatment of metastatic melanoma in 20 years. [139]
Pembrolizumab (Keytruda, formerly MK-3475 and lambrolizumab) was developed by Merck and first approved by the Food and Drug Administration in 2014 for the treatment of melanoma. It was later approved for metastatic non-small cell lung cancer and head and neck squamous cell carcinoma .
A 2016 clinical trial for non-small cell lung cancer failed to meet its primary endpoint for treatment in the first-line setting, but is FDA-approved in subsequent lines of therapy. [161] Pembrolizumab (Keytruda) is another PD1 inhibitor that was approved by the FDA in 2014. Pembrolizumab is approved to treat melanoma and lung cancer. [160]
A simple, low-cost treatment could save 22,000 new mothers' lives every year, scientists suggest. Julianne McShane. Updated May 11, 2023 at 7:58 AM. Ulises Ruiz.
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