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Low-density lipoprotein (LDL) is one of the five major groups of lipoprotein that transport all fat molecules around the body in extracellular water. [1] These groups, from least dense to most dense, are chylomicrons (aka ULDL by the overall density naming convention), very low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL ...
Cholesterol is the principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. [3] [4]Cholesterol is biosynthesized by all animal cells [citation needed] and is an essential structural and signaling component of animal cell membranes.
Low-density lipoproteins (LDL) carry 3,000 to 6,000 fat molecules (phospholipids, cholesterol, triglycerides, etc.) around the body. LDL particles are sometimes referred to as "bad" lipoprotein because concentrations of two kinds of LDL (sd-LDL and LPA), correlate with atherosclerosis progression.
Chylomicron structure ApoA, ApoB, ApoC, ApoE (apolipoproteins); T (triacylglycerol); C (cholesterol); green (phospholipids). Chylomicrons transport lipids absorbed from the intestine to adipose, cardiac, and skeletal muscle tissue, where their triglyceride components are hydrolyzed by the activity of the lipoprotein lipase, allowing the released free fatty acids to be absorbed by the tissues.
Lipids are a group of biological macromolecules that have a multitude of functions in the body. [ 1 ] [ 2 ] [ 3 ] Clinical studies on lipid metabolism in the body have led to developments in therapeutic lipidology for disorders such as cardiovascular disease.
[2] [3] The majority of lipids found in the human body from ingesting food are triglycerides and cholesterol. [4] Other types of lipids found in the body are fatty acids and membrane lipids . Lipid metabolism is often considered the digestion and absorption process of dietary fat; however, there are two sources of fats that organisms can use to ...
The liver converts unburned food metabolites into very low density lipoproteins (VLDL) and secretes them into plasma where they are converted to intermediate-density lipoproteins(IDL), which thereafter are converted to low-density lipoprotein (LDL) particles and non-esterified fatty acids, which can affect other body cells.
3990 15450 Ensembl ENSG00000166035 ENSMUSG00000032207 UniProt P11150 P27656 RefSeq (mRNA) NM_000236 NM_008280 NM_001324472 NM_001324473 RefSeq (protein) NP_000227 NP_001311401 NP_001311402 NP_032306 Location (UCSC) Chr 15: 58.41 – 58.57 Mb Chr 9: 70.71 – 70.86 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Hepatic lipase (HL), also called hepatic triglyceride lipase (HTGL) or ...