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Trimethylamine N-oxide (TMAO) is an organic compound with the formula (CH 3) 3 NO. It is in the class of amine oxides. Although the anhydrous compound is known, trimethylamine N-oxide is usually encountered as the dihydrate. Both the anhydrous and hydrated materials are white, water-soluble solids.
Normally, the FMO3 enzyme converts fishy-smelling trimethylamine into trimethylamine N-oxide which has no odor. If the enzyme is missing or its activity is reduced because of a mutation in the FMO3 gene, trimethylamine is not broken down and instead builds up in the body. As the compound is released in a person's sweat, urine, and breath, it ...
FMO3 is the primary enzyme in humans which catalyzes the N-oxidation of trimethylamine into trimethylamine N-oxide; [8] [10] FMO1 also does this, but to a much lesser extent than FMO3. [13] [14] Genetic deficiencies of the FMO3 enzyme cause primary trimethylaminuria, also known as "fish odor syndrome".
The microbiota – all the microorganisms in the body, can contribute to atherosclerosis in many ways: modulation of the immune system, changes in metabolism, processing of nutrients and production of certain metabolites that can get into blood circulation. [142] One such metabolite, produced by gut bacteria, is trimethylamine N-oxide (TMAO ...
Trimethylamine (TMA) is an organic compound with the formula N(CH 3) 3.It is a trimethylated derivative of ammonia.TMA is widely used in industry. [5] [6] At higher concentrations it has an ammonia-like odor, and can cause necrosis of mucous membranes on contact. [7]
On the flip side, there are also foods you should avoid or limit for a healthy brain. We recently reported how regularly eating processed red meat—like bacon, sausage, ham and bologna—may ...
Graphic depicting the human skin microbiota, with relative prevalences of various classes of bacteria. The human microbiome is the aggregate of all microbiota that reside on or within human tissues and biofluids along with the corresponding anatomical sites in which they reside, [1] [2] including the gastrointestinal tract, skin, mammary glands, seminal fluid, uterus, ovarian follicles, lung ...
Trimethylamine N-oxide reductase has the EC number 1.7.2.3, and these components refer to the following enzyme classifications: EC 1 enzymes are oxidoreductase enzymes, where an oxidation reduction reaction occurs, and the substrate being oxidized is either an oxygen or hydrogen donor